MK-801 impairs working memory on the Trial-Unique Nonmatch-to-Location test in mice, but this is not exclusively mediated by NMDA receptors on PV+ interneurons or forebrain pyramidal cells
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108103
Abstract: NMDA receptors are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: NMDAr hypofunction) is a candidate mechanism explaining working memory impairment in schizophrenia. However, the cellular… read more here.
Keywords: hypofunction; working memory; mice; pyramidal cells ... See more keywords
Schizophrenia-Like Dopamine Release Abnormalities in a Mouse Model of NMDA Receptor Hypofunction
Sign Up to like & getrecommendations! Published in 2019 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby003
Abstract: Abstract Amphetamine-induced augmentation of striatal dopamine and its blunted release in prefrontal cortex (PFC) is a hallmark of schizophrenia pathophysiology. Although N-methyl-D-aspartate receptor (NMDAR) hypofunction is also implicated in schizophrenia, it remains unclear whether NMDAR… read more here.
Keywords: schizophrenia; hypofunction; dopamine release; mice ... See more keywords
GABABR activation partially normalizes acute NMDAR hypofunction oscillatory abnormalities but fails to rescue sensory processing deficits
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15602
Abstract: Cognitive deficits and impaired sensory processing are hallmarks of several neurodevelopmental and neuropsychiatric disorders. N‐methyl‐d‐aspartate receptor (NMDAR) hypofunction contributes to these deficits by disrupting the excitation‐to‐inhibition balance in neuronal networks. Although preclinical data suggest that… read more here.
Keywords: sensory processing; fails rescue; hypofunction; partially normalizes ... See more keywords
Relationships Between Test Results for Oral Hypofunction, Subjective Frailty Symptoms and Oral Health-Related Quality of Life of Japanese Dental Outpatients: A Multicentre, Cross-Sectional Study.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of oral rehabilitation"
DOI: 10.1111/joor.13858
Abstract: BACKGROUND Oral hypofunction is the stage before oral dysfunction. The subjective symptoms of poor oral function and the decline in oral health-related quality of life (OHRQoL) that occur in the oral hypofunction stage can be… read more here.
Keywords: oral health; oral hypofunction; hypofunction; score ... See more keywords
Association Between Oral Hypofunction and Maximum Gait Speed in Older Adults: A Cross-Sectional Study.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of oral rehabilitation"
DOI: 10.1111/joor.13910
Abstract: BACKGROUND Previous studies have reported an association between oral hypofunction and normal gait speed as a marker for physical function; however, the association between maximum gait speed as a more sensitive marker for physical function… read more here.
Keywords: gait speed; oral hypofunction; hypofunction; maximum gait ... See more keywords
Association of the Oral Frailty Index-8 With the Diagnosis and Results of Oral Hypofunction Testing.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of oral rehabilitation"
DOI: 10.1111/joor.13966
Abstract: BACKGROUND Oral frailty is associated with physical frailty and the risk of requiring nursing care and death in older people. The Oral Frailty Index-8 (OFI-8) was developed for self-assessment of oral frailty, assuming that high-risk… read more here.
Keywords: diagnosis; oral frailty; oral hypofunction; hypofunction ... See more keywords
Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811211008560
Abstract: Background: Cognitive deficits profoundly impact on the quality of life of patients with schizophrenia. Alterations in brain derived neurotrophic factor (BDNF) signalling, which regulates synaptic function through the activation of full-length tropomyosin-related kinase B receptors… read more here.
Keywords: hypofunction; hippocampus; pfc; bdnf signalling ... See more keywords
Mesenchymal stromal/stem cell therapy for radiation-induced salivary gland hypofunction in animal models: a protocol for a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Systematic Reviews"
DOI: 10.1186/s13643-022-01943-2
Abstract: Background Salivary gland (SG) hypofunction (objectively reduced saliva flow rate) and xerostomia (subjective sensation of dry mouth) are common and burdensome side effects of radiotherapy to the head and neck region. Currently, only sparse symptomatic… read more here.
Keywords: hypofunction; therapy; review; radiation induced ... See more keywords
Posture Deficits and Recovery After Unilateral Vestibular Loss: Early Rehabilitation and Degree of Hypofunction Matter
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Human Neuroscience"
DOI: 10.3389/fnhum.2021.776970
Abstract: Postural instability and balance impairment are disabling symptoms in patients with acute unilateral peripheral vestibular hypofunction (UVH). Vestibular rehabilitation (VR) is known to improve the vestibular compensation process, but (1) its effect on posture recovery… read more here.
Keywords: posture; hypofunction; gain; rehabilitation ... See more keywords
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11102050
Abstract: Radiotherapy for head-and-neck cancers frequently causes long-term hypofunction of salivary glands that severely compromises quality of life and is difficult to treat. Here, we studied effects and mechanisms of Sphingosine-1-phosphate (S1P), a versatile signaling sphingolipid,… read more here.
Keywords: induced salivary; s1p; endothelial cells; hypofunction ... See more keywords
Effects of Sarcosine (N-methylglycine) on NMDA (N-methyl-D-aspartate) Receptor Hypofunction Induced by MK801: In Vivo Calcium Imaging in the CA1 Region of the Dorsal Hippocampus
Sign Up to like & getrecommendations! Published in 2024 at "Brain Sciences"
DOI: 10.3390/brainsci14111150
Abstract: Background: Hypofunction of the glutamate system in the brain is one of the pathophysiological hypotheses for schizophrenia. Accumulating animal and clinical studies show that sarcosine (N-methylglycine), a glycine transporter-1 inhibitor, is effective in ameliorating the… read more here.
Keywords: sarcosine methylglycine; receptor hypofunction; hypofunction; induced mk801 ... See more keywords