MK-801 impairs working memory on the Trial-Unique Nonmatch-to-Location test in mice, but this is not exclusively mediated by NMDA receptors on PV+ interneurons or forebrain pyramidal cells
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108103
Abstract: NMDA receptors are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: NMDAr hypofunction) is a candidate mechanism explaining working memory impairment in schizophrenia. However, the cellular… read more here.
Keywords: hypofunction; working memory; mice; pyramidal cells ... See more keywords
Schizophrenia-Like Dopamine Release Abnormalities in a Mouse Model of NMDA Receptor Hypofunction
Sign Up to like & getrecommendations! Published in 2019 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby003
Abstract: Abstract Amphetamine-induced augmentation of striatal dopamine and its blunted release in prefrontal cortex (PFC) is a hallmark of schizophrenia pathophysiology. Although N-methyl-D-aspartate receptor (NMDAR) hypofunction is also implicated in schizophrenia, it remains unclear whether NMDAR… read more here.
Keywords: schizophrenia; hypofunction; dopamine release; mice ... See more keywords
GABABR activation partially normalizes acute NMDAR hypofunction oscillatory abnormalities but fails to rescue sensory processing deficits
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15602
Abstract: Cognitive deficits and impaired sensory processing are hallmarks of several neurodevelopmental and neuropsychiatric disorders. N‐methyl‐d‐aspartate receptor (NMDAR) hypofunction contributes to these deficits by disrupting the excitation‐to‐inhibition balance in neuronal networks. Although preclinical data suggest that… read more here.
Keywords: sensory processing; fails rescue; hypofunction; partially normalizes ... See more keywords
Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811211008560
Abstract: Background: Cognitive deficits profoundly impact on the quality of life of patients with schizophrenia. Alterations in brain derived neurotrophic factor (BDNF) signalling, which regulates synaptic function through the activation of full-length tropomyosin-related kinase B receptors… read more here.
Keywords: hypofunction; hippocampus; pfc; bdnf signalling ... See more keywords
Mesenchymal stromal/stem cell therapy for radiation-induced salivary gland hypofunction in animal models: a protocol for a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Systematic Reviews"
DOI: 10.1186/s13643-022-01943-2
Abstract: Background Salivary gland (SG) hypofunction (objectively reduced saliva flow rate) and xerostomia (subjective sensation of dry mouth) are common and burdensome side effects of radiotherapy to the head and neck region. Currently, only sparse symptomatic… read more here.
Keywords: hypofunction; therapy; review; radiation induced ... See more keywords
Posture Deficits and Recovery After Unilateral Vestibular Loss: Early Rehabilitation and Degree of Hypofunction Matter
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Human Neuroscience"
DOI: 10.3389/fnhum.2021.776970
Abstract: Postural instability and balance impairment are disabling symptoms in patients with acute unilateral peripheral vestibular hypofunction (UVH). Vestibular rehabilitation (VR) is known to improve the vestibular compensation process, but (1) its effect on posture recovery… read more here.
Keywords: posture; hypofunction; gain; rehabilitation ... See more keywords
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages
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DOI: 10.3390/antiox11102050
Abstract: Radiotherapy for head-and-neck cancers frequently causes long-term hypofunction of salivary glands that severely compromises quality of life and is difficult to treat. Here, we studied effects and mechanisms of Sphingosine-1-phosphate (S1P), a versatile signaling sphingolipid,… read more here.
Keywords: induced salivary; s1p; endothelial cells; hypofunction ... See more keywords
Relationship between Oral Hypofunction and Sarcopenia in Community-Dwelling Older Adults: The Otassha Study
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DOI: 10.3390/ijerph18126666
Abstract: Oral hypofunction, resulting from a combined decrease in multiple oral functions, may affect systemic-condition deterioration; however, few studies have examined the association between oral hypofunction and general health among older adults. In this cross-sectional study,… read more here.
Keywords: oral hypofunction; hypofunction; relationship oral; hypofunction sarcopenia ... See more keywords
Associations between Oral Hypofunction Tests, Age, and Sex
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DOI: 10.3390/ijerph181910256
Abstract: Oral function declines in older individuals due to disease and age-related changes, making them vulnerable to oral and physical frailty. Therefore, it is important to manage the decline in oral function in older outpatients. Oral… read more here.
Keywords: oral hypofunction; oral function; hypofunction; age ... See more keywords
Relationship between Oral Hypofunction, and Protein Intake: A Cross-Sectional Study in Local Community-Dwelling Adults
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DOI: 10.3390/nu13124377
Abstract: Few studies have investigated the relationship between nutritional status and comprehensive assessment of oral hypofunction, especially protein intake-related sarcopenia. Thus, we explored these relationships in a large-scale cross-sectional cohort study using the seven-item evaluation for… read more here.
Keywords: hypofunction; cross sectional; community dwelling; protein intake ... See more keywords