Trends in HbA1c thresholds for initiation of hypoglycemic agents: Impact of changed recommendations for older and frail patients
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DOI: 10.1002/pds.5129
Abstract: Less strict glycated hemoglobin (HbA1c) thresholds have been recommended in older and/or frail type 2 diabetes (T2D) patients than in younger and less frail patients for initiating hypoglycemic agents since 2011. We aimed to assess… read more here.
Keywords: frail patients; trends hba1c; hypoglycemic agents; thresholds initiation ... See more keywords
Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42)
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DOI: 10.1097/md.0000000000006122
Abstract: Abstract Little is known about the relationships between patient factors and the antihyperglycemic agents that have been prescribed as initial therapy by diabetes specialists for patients with type 2 diabetes. Moreover, there has been little… read more here.
Keywords: diabetes specialists; patients type; initial monotherapy; type diabetes ... See more keywords
Meta-analysis of the association between new hypoglycemic agents and digestive diseases
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DOI: 10.1097/md.0000000000030072
Abstract: Background: New hypoglycemic agents include sodium-glucose cotransporter-2 inhibitors (SGLT2is), glucagon-like peptide 1 receptor agonists (GLP1RAs), and dipeptidyl peptidase-4 inhibitors (DPP4is). The association between each class of these new hypoglycemic drugs and the risks of various… read more here.
Keywords: meta analysis; kinds digestive; hypoglycemic agents; digestive diseases ... See more keywords
New insights into the older hypoglycemic agents in type 2 diabetes therapy
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DOI: 10.1111/1753-0407.13096
Abstract: Type 2 diabetes (T2D) is one of the leading causes of morbidity and mortality, consuming a significant proportion of public health spending. Following lifestyle changes, the most common treatment for T2D is the addition of… read more here.
Keywords: agents type; type diabetes; new insights; insights older ... See more keywords
Dipeptidyl peptidase‐4 inhibitors as preferable oral hypoglycemic agents in terms of treatment satisfaction: Results from a multicenter, 12‐week, open label, randomized controlled study in Japan (PREFERENCE 4 study)
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DOI: 10.1111/jdi.12659
Abstract: To compare the treatment satisfaction of four classes of oral hypoglycemic agents (OHAs): dipeptidyl peptidase‐4 (DPP‐4) inhibitors, α‐glucosidase inhibitors (αGI), biguanides (BG) and sulfonylureas (SU), which are common initial treatments for type 2 diabetes mellitus… read more here.
Keywords: hypoglycemic agents; oral hypoglycemic; treatment satisfaction; study ... See more keywords
Evaluation of the HbA1c Reduction Cut Point for a Nonglycemic Effect on Cardiovascular Benefit of Hypoglycemic Agents in Patients with Type 2 Diabetes Based on Endpoint Events
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DOI: 10.1155/2018/8457538
Abstract: Background Atherosclerotic cardiovascular disease (ASCVD) is a major cause of death among patients with diabetes but can be improved by certain hypoglycemic agents. However, adjudicating criteria on whether improvements are a glycemic or nonglycemic effect… read more here.
Keywords: reduction; effect; nonglycemic effect; hypoglycemic agents ... See more keywords
Effectiveness and safety of exenatide in Korean patients with type 2 diabetes inadequately controlled with oral hypoglycemic agents: an observational study in a real clinical practice
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DOI: 10.1186/s12902-017-0220-4
Abstract: BackgroundRandomized clinical trials have shown the efficacy and safety of short-acting exenatide in patients with type 2 diabetes mellitus (T2DM). The aim of this observational study was to investigate the effectiveness and safety of exenatide… read more here.
Keywords: controlled oral; safety; study; oral hypoglycemic ... See more keywords
Directed Search of Biologically Active Compounds among Hydrogenated Isoindolylalkyl(alkylaryl-,aryl-)carboxylic Acids with Quinazoline Fragment that Modify the Carbohydrate Metabolism: Design, Synthesis and Modification.
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DOI: 10.17344/acsi.2018.4731
Abstract: An effective synthesis of (3H-quinazoline-4-ylidene)hydrazides of N-carboxyalkyl-(arylalkyl-,aryl-)isoindoline-1,3-diones, using activated N-protected aminoacids and 4-hydrazinoquinazoline was proposed in the framework methodology of directed search of hypoglycemic agents (fragment-oriented design, molecular docking). These hydrazides prepared via cyclocondensation under… read more here.
Keywords: directed search; hypoglycemic agents; synthesis; alkylaryl aryl ... See more keywords
Virtual Screening-Based Discovery of Potent Hypoglycemic Agents: In Silico, Chemical Synthesis and Biological Study.
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DOI: 10.2174/1573409915666191018121558
Abstract: BACKGROUND Dipeptidyl peptidase IV has been reported to be an important target for the development and discovery of new therapies for diabetes mellitus type II. Objective: The main aim of this study is to discover… read more here.
Keywords: virtual screening; study; discovery; potent hypoglycemic ... See more keywords
[The epidemiological characteristics and adherence to hypoglycemic agents of ischemic stroke patients with diabetes].
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DOI: 10.3760/cma.j.cn112150-20210530-00523
Abstract: Objective: To investigate the epidemiological characteristics and adherence to hypoglycemic agents of the ischemic stroke patients combined with diabetes. Methods: The study recruited 23 044 ischemic stroke cases from 2013-2015 screening period of China National… read more here.
Keywords: ischemic stroke; epidemiological characteristics; adherence hypoglycemic; stroke patients ... See more keywords