Global hypomethylation is an independent prognostic factor in diffuse large B cell lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24751
Abstract: Global hypomethylation has been linked to disease progression in several cancers, but has not been reported for Diffuse Large B Cell Lymphoma (DLBCL). This study aimed to assess global methylation in DLBCL and describe its… read more here.
Keywords: methylation; global hypomethylation; cfdna; large cell ... See more keywords
The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.11.082
Abstract: DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated… read more here.
Keywords: methylation; prmt6; hypomethylation; cancer ... See more keywords
Hypomethylation of BORIS is a promising prognostic biomarker in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.07.077
Abstract: The brother of the regulator of the imprinted site (BORIS), an 11 zinc finger (ZF) protein, is a paralogue of CCCTC-binding factor (CTCF), involves in a few crucial events of chromatin functions, complex transcription regulation… read more here.
Keywords: hepatocellular carcinoma; hcc; biomarker; boris ... See more keywords
Simple in vitro generation of human leukocyte antigen-G-expressing T-regulatory cells through pharmacological hypomethylation for adoptive cellular immunotherapy against graft-versus-host disease.
Sign Up to like & getrecommendations! Published in 2017 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2017.01.004
Abstract: BACKGROUND Major barriers in using classical FOXP3+ regulatory T cells (Tregs) in clinical practice are their low numbers in the circulation, the lack of specific cell surface markers for efficient purification and the loss of… read more here.
Keywords: regulatory cells; hla; human leukocyte; expression ... See more keywords
LINE-1 hypomethylation is associated to specific clinico-pathological features in Stage I non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2017.03.003
Abstract: OBJECTIVES We hypothesize that selected genetic and/or epigenetic changes associated with advanced tumours may help identifying early non-small cell lung cancers (NSCLCs) that recur after resection. Among epigenetic changes, long interspersed nuclear element-1 (LINE-1) hypomethylation… read more here.
Keywords: line hypomethylation; line; hypomethylation; cancer ... See more keywords
LINE-1 hypomethylation is not a common event in preneoplastic stages of gastric carcinogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05143-0
Abstract: LINE-1 hypomethylation is widely accepted as marker for global genomic DNA hypomethylation, which is a frequent event in cancer. The aim of the study was to evaluate LINE-1 methylation status at different stages of gastric… read more here.
Keywords: line hypomethylation; line; hypomethylation; line methylation ... See more keywords
Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome with distinctive genome-wide DNA hypomethylation.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac291
Abstract: Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is in most cases-caused by mutations in either DNMT3B, ZBTB24, CDCA7, or HELLS. However, the causative genes of a few ICF patients remain unknown. We, herein, identified… read more here.
Keywords: icf syndrome; methylation; centromeric instability; immunodeficiency centromeric ... See more keywords
The genome-wide mutational consequences of DNA hypomethylation
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1101/2022.10.04.510776
Abstract: DNA methylation is important for establishing and maintaining cell identity and for genomic stability. This is achieved by regulating the accessibility of regulatory and transcriptional elements and the compaction of subtelomeric, centromeric, and other inactive… read more here.
Keywords: dna methylation; genome wide; mutational consequences; global hypomethylation ... See more keywords
TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer.
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DOI: 10.1158/0008-5472.can-17-2082
Abstract: Both gains and losses of DNA methylation are common in cancer, but the factors controlling this balance of methylation remain unclear. Triple-negative breast cancer (TNBC), a subtype that does not overexpress hormone receptors or HER2/NEU,… read more here.
Keywords: tet1; breast cancer; hypomethylation; cancer ... See more keywords
Hypomethylation-Linked Activation of PLCE1 Impedes Autophagy and Promotes Tumorigenesis through MDM2-Mediated Ubiquitination and Destabilization of p53
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-1912
Abstract: These findings identify hypomethylation-mediated activation of PLCE1 as a potential oncogene that blocks cellular autophagy of esophageal carcinoma by facilitating the MDM2-dependent ubiquitination of p53 and subsequent degradation. Esophageal squamous cell carcinoma (ESCC) is one… read more here.
Keywords: plce1; hypomethylation; ubiquitination; activation plce1 ... See more keywords
S100P Expression via DNA Hypomethylation Promotes Cell Growth in the Sessile Serrated Adenoma/Polyp-Cancer Sequence
Sign Up to like & getrecommendations! Published in 2021 at "Digestion"
DOI: 10.1159/000512575
Abstract: Background/Aims: Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor lesion of colon cancer. Although the relevance of DNA hypermethylation in the SSA/P-cancer sequence is well documented, the role of DNA hypomethylation is unknown. We investigated… read more here.
Keywords: ssa; cancer sequence; hypomethylation; cancer ... See more keywords