Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice
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DOI: 10.1371/journal.pone.0193446
Abstract: Reduced expression of Sp4, the murine homolog of human SP4, a risk gene of multiple psychiatric disorders, led to N-methyl-D-aspartate (NMDA) hypofunction in mice, producing behavioral phenotypes reminiscent of schizophrenia, including hypersensitivity to ketamine. As… read more here.
Keywords: theta; power; sp4 hypomorphic; hypomorphic mice ... See more keywords