The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin‐1α release from human blood cells
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DOI: 10.1111/imm.13584
Abstract: Interleukin‐1 alpha (IL‐1α) is a powerful cytokine that drives inflammation and modulates adaptive immunity. Due to these powerful effects, IL‐1α is controlled at multiple levels from transcription to cleavage and release from the cell. Genome‐wide… read more here.
Keywords: minor allele; rs17561; release; hypomorphic mutation ... See more keywords