RNA demethylase ALKBH5 regulates hypopharyngeal squamous cell carcinoma ferroptosis by posttranscriptionally activating NFE2L2/NRF2 in an m6A‐IGF2BP2‐dependent manner
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24514
Abstract: Having emerged as the most abundant posttranscriptional internal mRNA modification in eukaryotes, N6‐methyladenosine (m6A) has attracted tremendous scientific interest in recent years. However, the functional importance of the m6A methylation machinery in ferroptosis regulation in… read more here.
Keywords: cell carcinoma; hypopharyngeal squamous; squamous cell; m6a ... See more keywords
An MRI-based radiomics-clinical nomogram for the overall survival prediction in patients with hypopharyngeal squamous cell carcinoma: a multi-cohort study
Sign Up to like & getrecommendations! Published in 2021 at "European Radiology"
DOI: 10.1007/s00330-021-08292-z
Abstract: To explore whether radiomics features extracted from pre-treatment magnetic resonance imaging (MRI) can predict the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma. A total of 190 patients with hypopharyngeal squamous cell carcinoma… read more here.
Keywords: squamous cell; cell carcinoma; patients hypopharyngeal; hypopharyngeal squamous ... See more keywords
Cross-comparison of microbiota in the oropharynx, hypopharyngeal squamous cell carcinoma and their adjacent tissues through quantitative microbiome profiling
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DOI: 10.1080/20002297.2022.2073860
Abstract: ABSTRACT Aims To clarify the absolute abundance of microbial communities on hypopharyngeal squamous cell carcinoma and their correlation to those in the oropharynx. Methods Clinical data, swabs, and tissue samples from 27 HPSCC patients were… read more here.
Keywords: cell carcinoma; microbiome profiling; hypopharyngeal squamous; squamous cell ... See more keywords
Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma
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DOI: 10.1186/s12957-020-01866-z
Abstract: Background This study evaluated the treatment outcomes of the primary surgery (PS) or concurrent chemoradiotherapy (CCRT) as the initial treatment for hypopharyngeal squamous cell carcinoma (HPSCC). Methods This retrospective cohort study included patients with stages… read more here.
Keywords: cell carcinoma; treatment; squamous cell; stage iva ... See more keywords
The Pretreatment Neutrophil-to-Lymphocyte Ratio is a Prognostic Determinant of T3–4 Hypopharyngeal Squamous Cell Carcinoma
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DOI: 10.1245/s10434-017-5865-8
Abstract: ObjectiveThis study aimed to investigate the clinicopathological factors that influence recurrence and survival in patients who undergo operations for T3–4 hypopharyngeal squamous cell carcinomas (SCCs).Materials and MethodsOne hundred and five patients who underwent surgery between… read more here.
Keywords: pretreatment neutrophil; squamous cell; disease; ratio ... See more keywords
Diagnostic Significance of Downregulated circMORC3 as a Molecular Biomarker of Hypopharyngeal Squamous Cell Carcinoma: A Pilot Study
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s235888
Abstract: Background Circular RNAs (circRNAs) have proven to be of great clinical significance as diagnostic biomarkers in various cancers. Here, we investigate the expression of circMORC3 in hypopharyngeal squamous cell carcinoma (HSCC), exploring whether it could… read more here.
Keywords: expression; expression levels; biomarker; hypopharyngeal squamous ... See more keywords
The Prognostic Prediction Value of Positive Lymph Nodes Numbers for the Hypopharyngeal Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.898483
Abstract: Background The current American Joint Committee on Cancer (AJCC) system only considered the importance of the size and laterality of lymph nodes while not the positive lymph node number (PLNN) for hypopharyngeal squamous cell carcinoma… read more here.
Keywords: cell carcinoma; positive lymph; hypopharyngeal squamous; squamous cell ... See more keywords
MRI-based radiomics analysis for preoperative evaluation of lymph node metastasis in hypopharyngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.936040
Abstract: Objective To investigate the role of pre-treatment magnetic resonance imaging (MRI) radiomics for the preoperative prediction of lymph node (LN) metastasis in patients with hypopharyngeal squamous cell carcinoma (HPSCC). Methods A total of 155 patients… read more here.
Keywords: metastasis; node metastasis; hypopharyngeal squamous; squamous cell ... See more keywords
Increased response to TPF chemotherapy promotes immune escape in hypopharyngeal squamous cell carcinoma
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DOI: 10.3389/fphar.2022.1097197
Abstract: Background: There is an urgent need to identify which patients would benefit from TPF chemotherapy in hypopharyngeal squamous cell carcinoma (HPSCC) and to explore new combinations to improve the treatment effect. Materials and methods: Gene-expression… read more here.
Keywords: hypopharyngeal squamous; squamous cell; tpf chemotherapy; response ... See more keywords
Solamargine Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma by Decreasing LncRNA HOXA11-As Expression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.887387
Abstract: Hypopharyngeal squamous cell carcinoma (HSCC) is one of the high mortality cancers with a poor prognosis, which is driving the development of new chemotherapeutic agents. We identified the anticancer effects of a natural compound, solamargine… read more here.
Keywords: cell carcinoma; hypopharyngeal squamous; squamous cell; expression ... See more keywords