Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo3991
Abstract: Recent genome-wide association studies corroborate classical research on developmental programming indicating that obesity is primarily a neurodevelopmental disease strongly influenced by nutrition during critical ontogenic windows. Epigenetic mechanisms regulate neurodevelopment; however, little is known about… read more here.
Keywords: mouse hypothalamic; arcuate nucleus; sex; sex specific ... See more keywords
Proteome Analysis of the Hypothalamic Arcuate Nucleus in Chronic High-Fat Diet-Induced Obesity
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DOI: 10.1155/2021/3501770
Abstract: The hypothalamus plays a central role in the integrated regulation of feeding and energy homeostasis. The hypothalamic arcuate nucleus (ARC) contains a population of neurons that express orexigenic and anorexigenic factors and is thought to… read more here.
Keywords: fat diet; arcuate nucleus; analysis; fat ... See more keywords
Ultradian Rhythms in the Hypothalamic Arcuate Nucleus Kisspeptin Neurons and Developmental Processes
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DOI: 10.14348/molcells.2020.0066
Abstract: Numerous physiological processes in nature have multiple oscillations within 24 h, that is, ultradian rhythms. Compared to the circadian rhythm, which has a period of approximately one day, these short oscillations range from seconds to… read more here.
Keywords: arcuate nucleus; rhythms; developmental processes; ultradian rhythms ... See more keywords
One-month of high-intensity exercise did not change the food intake and the hypothalamic arcuate nucleus proopiomelanocortin and neuropeptide Y expression levels in male Wistar rats
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DOI: 10.2478/enr-2019-0002
Abstract: Abstract Objective. The hypothalamic arcuate nucleus proopiomelanocortin (POMC) and neuropeptide Y (NPY) circuitries are involved in the inhibition and stimulation of the appetite, respectively. The aim of this study was to investigate the effects of… read more here.
Keywords: arcuate nucleus; food intake; one month; exercise ... See more keywords
Distinct Firing Activities of the Hypothalamic Arcuate Nucleus Neurons to Appetite Hormones
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DOI: 10.3390/ijms23052609
Abstract: The hypothalamic arcuate nucleus (Arc) is a central unit that controls the appetite through the integration of metabolic, hormonal, and neuronal afferent inputs. Agouti-related protein (AgRP), proopiomelanocortin (POMC), and dopaminergic neurons in the Arc differentially… read more here.
Keywords: firing rate; firing activities; arcuate nucleus; dopaminergic neurons ... See more keywords