Palmitate-induced autophagy liberates monounsaturated fatty acids and increases Agrp expression in hypothalamic cells
Sign Up to like & getrecommendations! Published in 2019 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2019.1696407
Abstract: ABSTRACT Fatty acids regulate food intake, although the exact mechanism remains unknown. Emerging evidence suggests that intracellular free fatty acids generated by starvation-induced autophagy regulate food intake. Starvation for 6 h elevated fatty acids such as… read more here.
Keywords: palmitate induced; fatty acids; agrp expression; induced autophagy ... See more keywords
Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Brain"
DOI: 10.1186/s13041-021-00777-8
Abstract: Palmitate is a saturated fatty acid that is well known to induce endoplasmic reticulum (ER) stress and autophagy. A high-fat diet increases the palmitate level in the hypothalamus, the main region of the brain regulating… read more here.
Keywords: starvation induced; starvation; palmitate; inhibiting phagy ... See more keywords
LKB1 alleviates high glucose- and high fat-induced inflammation and the expression of GnRH and sexual precocity-related genes, in mouse hypothalamic cells by activating the AMPK/FOXO1 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12659
Abstract: Precocious puberty (PP) is a developmental disorder. Hypothalamic cells can produce gonadotropin-releasing hormone (GnRH), the final output of neuroendocrine regulation that occurs during puberty. The aim of the present study was to investigate the role… read more here.
Keywords: ampk foxo1; foxo1 signaling; inflammation; expression ... See more keywords