Hypothalamic Inflammation at a Crossroad of Somatic Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0631-4
Abstract: Various hypothalamic nuclei function as central parts of regulators that maintain homeostasis of the organism. Recently, findings have shown that inflammation in the hypothalamus may significantly affect activity of these homeostats and consequently participate in… read more here.
Keywords: crossroad somatic; inflammation crossroad; inflammation; somatic diseases ... See more keywords
The effects of overnight nutrient intake on hypothalamic inflammation in a free-choice diet-induced obesity rat model
Sign Up to like & getrecommendations! Published in 2018 at "Appetite"
DOI: 10.1016/j.appet.2017.10.006
Abstract: Consumption of fat and sugar induces hyperphagia and increases the prevalence of obesity and diabetes type 2. Low-grade inflammation in the hypothalamus, a key brain area involved in the regulation of energy homeostasis is shown… read more here.
Keywords: free choice; fat sugar; inflammation; hypothalamic inflammation ... See more keywords
CD1 is involved in diet-induced hypothalamic inflammation in obesity
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.01.011
Abstract: Obesity-associated hypothalamic inflammation plays an important role in the development of defective neuronal control of whole body energy balance. Because dietary fats are the main triggers of hypothalamic inflammation, we hypothesized that CD1, a lipid-presenting… read more here.
Keywords: induced hypothalamic; cd1; diet induced; hypothalamic inflammation ... See more keywords
Neuroinflammation and depressive disorder: The role of the hypothalamus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.03.005
Abstract: Data accumulated over the last two decades has demonstrated that hypothalamic inflammation plays an important role in the etiopathogenesis of the most prevalent diseases, such as cardiovascular diseases, metabolic syndrome, and even cancer. Recent findings… read more here.
Keywords: neuroinflammation depressive; depressive disorder; role; hypothalamic inflammation ... See more keywords
TGF-β1 down-regulation in the mediobasal hypothalamus attenuates hypothalamic inflammation and protects against diet-induced obesity.
Sign Up to like & getrecommendations! Published in 2018 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2018.04.005
Abstract: BACKGROUND The consumption of large amounts of dietary fats induces hypothalamic inflammation and impairs the function of the melanocortin system, leading to a defective regulation of caloric intake and whole-body energy expenditure. In mice fed… read more here.
Keywords: hypothalamic tgf; inflammation; tgf; hypothalamic inflammation ... See more keywords
Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101214
Abstract: Objective Hypothalamic inflammation and endoplasmic reticulum (ER) stress are extensively linked to leptin resistance and overnutrition-related diseases. Surgical intervention remains the most efficient long-term weight-loss strategy for morbid obesity, but mechanisms underlying sustained feeding suppression… read more here.
Keywords: gut; leptin; weight loss; rygb ... See more keywords
Is human obesity an inflammatory disease of the hypothalamus?
Sign Up to like & getrecommendations! Published in 2023 at "European journal of endocrinology"
DOI: 10.1093/ejendo/lvad030
Abstract: Obesity and its comorbidities are longstanding, challenging global health problems. Lack of exercise, overnutrition and especially the consumption of fat-rich foods are some of the most important factors leading to an increase in prevalence in… read more here.
Keywords: obesity; inflammatory; inflammatory disease; hypothalamic inflammation ... See more keywords
Anti‐aging drugs reduce hypothalamic inflammation in a sex‐specific manner
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12590
Abstract: Aging leads to hypothalamic inflammation, but does so more slowly in mice whose lifespan has been extended by mutations that affect GH/IGF‐1 signals. Early‐life exposure to GH by injection, or to nutrient restriction in the… read more here.
Keywords: aging drugs; age; sex specific; inflammation ... See more keywords
Cell and molecular mechanisms behind diet‐induced hypothalamic inflammation and obesity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12598
Abstract: Diet‐induced obesity (DIO) is associated with chronic, low‐grade inflammation in the hypothalamus, a key regulator of energy homeostasis. Current studies have revealed the involvement of different cell types, as well as cell and molecular mechanisms,… read more here.
Keywords: cell molecular; diet induced; inflammation; hypothalamic inflammation ... See more keywords
Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.131329
Abstract: There is increased interest in whether bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) achieve their profound weight-lowering effects in morbidly obese individuals through the brain. Hypothalamic inflammation is a well-recognized etiologic factor in obesity… read more here.
Keywords: gastric bypass; radiologic measures; inflammation; hypothalamic inflammation ... See more keywords
Attenuation of diet-induced hypothalamic inflammation following bariatric surgery in female mice
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine"
DOI: 10.1186/s10020-018-0057-y
Abstract: BackgroundExposure of rodents to chronic high-fat diet (HFD) results in upregulation of inflammatory markers and proliferation of microglia within the mediobasal hypothalamus. Such hypothalamic inflammation is associated with metabolic dysfunction, central leptin resistance, and maintenance… read more here.
Keywords: induced hypothalamic; female mice; mice; hypothalamic inflammation ... See more keywords