Long‐term priming of hypothalamic microglia is associated with energy balance disturbances under diet‐induced obesity
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DOI: 10.1002/glia.24217
Abstract: Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy balance regulation. A… read more here.
Keywords: energy balance; hypothalamic microglia; obesity; microglia ... See more keywords
Early life alcohol exposure primes hypothalamic microglia to later-life hypersensitivity to immune stress: possible epigenetic mechanism
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DOI: 10.1038/s41386-019-0326-7
Abstract: Growing evidence has shown that developmental alcohol exposure induces central nervous system inflammation and microglia activation, which may contribute to long-term health conditions, such as fetal alcohol spectrum disorders. These studies sought to investigate whether… read more here.
Keywords: hypothalamic microglia; exposure; alcohol exposure; life ... See more keywords
Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic Microglia Numbers, Ramification, and Phagocytic Cups
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DOI: 10.3389/fnins.2022.830399
Abstract: Microglia are a resident population of phagocytic immune cells that reside within the central nervous system (CNS). During gestation, they are highly sensitive to their surrounding environment and can alter their physiology to respond to… read more here.
Keywords: embryonic hypothalamic; gestational bpa; exposure; bpa ... See more keywords
Minocycline Reduces Hypothalamic Microglia Activation and Improves Metabolic Dysfunction in High Fat Diet-Induced Obese Mice
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DOI: 10.3389/fphys.2022.933706
Abstract: Obesity is associated with insulin resistance, glucose intolerance, inflammation, and altered neuronal activity in brain regions controlling metabolic functions including food intake, energy expenditure, and glucose homeostasis, such as the hypothalamus. In this study, we… read more here.
Keywords: hypothalamic microglia; high fat; microglia activation; minocycline ... See more keywords