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   Articles with "hypothalamic neurons" as a keyword



X-linked histone H3K27 demethylase Kdm6a regulates sexually dimorphic differentiation of hypothalamic neurons

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recommendations! Published in 2021 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-021-03945-0

Abstract: Several X-linked genes are involved in neuronal differentiation and may contribute to the generation of sex dimorphisms in the brain. Previous results showed that XX hypothalamic neurons grow faster, have longer axons, and exhibit higher… read more here.

Keywords: hypothalamic neurons; sex; differentiation; expression ... See more keywords

In vitro examination of microglia-neuron crosstalk with BV2 cells, and primary cultures of glia and hypothalamic neurons

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recommendations! Published in 2018 at "Heliyon"

DOI: 10.1016/j.heliyon.2018.e00730

Abstract: Microglia respond to environmental changes by releasing cytokines that beneficially or detrimentally affect surrounding cells in addition to functioning as the resident CNS macrophages. Interactions between glia and neurons participate in many critical brain functions… read more here.

Keywords: hypothalamic neurons; microglia; cultures glia; primary cultures ... See more keywords

Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights

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recommendations! Published in 2018 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2018.01.021

Abstract: Objective Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which hypothalamic neural circuits controlling… read more here.

Keywords: hypothalamic neurons; murine; rapid sensing; sensing leucine ... See more keywords

Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons

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recommendations! Published in 2020 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2019.10.028

Abstract: Spexin (SPX) is a novel satiety factor that putatively binds the galanin receptors R2 and R3 (GalR2/R3). SPX reduces body weight, and circulating SPX is decreased in obesity. It is unknown how SPX and its… read more here.

Keywords: hypothalamic neurons; galanin receptors; galr2 galr3; spx ... See more keywords
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Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses.

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recommendations! Published in 2018 at "Cell stem cell"

DOI: 10.1016/j.stem.2018.03.009

Abstract: The hypothalamus contains neurons that integrate hunger and satiety endocrine signals from the periphery and are implicated in the pathophysiology of obesity. The limited availability of human hypothalamic neurons hampers our understanding of obesity disease… read more here.

Keywords: hypothalamic neurons; obese patient; super obese; obesity ... See more keywords

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons

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recommendations! Published in 2017 at "Stem Cell Reports"

DOI: 10.1016/j.stemcr.2016.12.021

Abstract: Summary We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of these cells in modeling of a monogenic form of severe… read more here.

Keywords: hypothalamic neurons; pomc; stem cell; stem ... See more keywords

Concerted transcriptional regulation of the morphogenesis of hypothalamic neurons by ONECUT3

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-52762-z

Abstract: Acquisition of specialized cellular features is controlled by the ordered expression of transcription factors (TFs) along differentiation trajectories. Here, we find a member of the Onecut TF family, ONECUT3, expressed in postmitotic neurons that leave… read more here.

Keywords: transcriptional regulation; hypothalamic neurons; concerted transcriptional; regulation morphogenesis ... See more keywords

Investigating the role of an immediate early gene FOS as a potential regulator of autophagic response to hypoglycemia in embryonic hypothalamic neurons

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recommendations! Published in 2024 at "Clinical and Translational Science"

DOI: 10.1111/cts.13749

Abstract: Hypoglycemia‐associated autonomic failure (HAAF) is a well‐established complication of diabetes. Although HAAF has serious outcomes such as recurrent morbidity, coma, and death, the mechanisms of HAAF and its pathological components are largely unknown. Our previous… read more here.

Keywords: immediate early; early gene; hypothalamic neurons; response ... See more keywords

l-Type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis

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recommendations! Published in 2023 at "JCI Insight"

DOI: 10.1172/jci.insight.154925

Abstract: Hypothalamic neurons regulate body homeostasis by sensing and integrating changes in the levels of key hormones and primary nutrients (amino acids, glucose, and lipids). However, the molecular mechanisms that enable hypothalamic neurons to detect primary… read more here.

Keywords: energy bone; bone; hypothalamic neurons; homeostasis ... See more keywords

IGF1 Signaling Regulates Neuropeptide Expression in Hypothalamic Neurons Under Physiological and Pathological Conditions

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recommendations! Published in 2025 at "Endocrinology"

DOI: 10.1210/endocr/bqaf051

Abstract: Abstract Insulin-like growth factor 1 (IGF1) plays a critical role in metabolism and aging, but its role in the brain remains unclear. This study examined whether hypothalamic neurons respond to IGF1 and how its actions… read more here.

Keywords: igf1 signaling; hypothalamic neurons; regulates neuropeptide; signaling regulates ... See more keywords

OR01-01 Novel Anti-obesity Phytohormone Promotes Cellular Insulin Sensitivity in Hypothalamic Neurons

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recommendations! Published in 2024 at "Journal of the Endocrine Society"

DOI: 10.1210/jendso/bvae163.2406

Abstract: Abstract C.X. Zhang: None. C. Lieu: None. W. He: None. D.D. Belsham: None. Obesity is a global epidemic and is associated with dangerous comorbidities, such as type 2 diabetes mellitus (T2DM). Insulin is sensed by… read more here.

Keywords: insulin; obesity; hypothalamic neurons; insulin resistance ... See more keywords