Hypothalamic Obesity: 4 Years of the International Registry of Hypothalamic Obesity Disorders
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DOI: 10.1002/oby.22315
Abstract: Hypothalamic obesity (HyOb) is a rare cause of rapid weight gain and early metabolic comorbidities. Effective treatment strategies are limited. The registry collected participant data and compared treatment approaches. read more here.
Keywords: international registry; years international; obesity years; hypothalamic obesity ... See more keywords
NURS-12. MAKING SURVIVORS HEALTHIER: A MULTIDISCIPLINARY APPROACH TO HYPOTHALAMIC OBESITY
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DOI: 10.1093/neuonc/noaa222.631
Abstract: Abstract BACKGROUND Pediatric survivors of hypothalamic/suprasellar tumors have significant morbidities that greatly impact their quality of life. Management of hypothalamic obesity has traditionally fallen between multiple subspecialties without a timely and comprehensive approach. METHODS A… read more here.
Keywords: making survivors; nurs making; hypothalamic obesity; approach ... See more keywords
Novel clinical algorithm for hypothalamic obesity in youth with brain tumours and factors associated with excess weight gain
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DOI: 10.1111/ijpo.12903
Abstract: A standardized approach for identifying and treating hypothalamic obesity (HO) in children with hypothalamic tumours is lacking. read more here.
Keywords: clinical algorithm; hypothalamic obesity; obesity youth; algorithm hypothalamic ... See more keywords
Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity
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DOI: 10.1210/en.2016-1665
Abstract: Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase 2-inhibitor beloranib (ZGN-440) in 2 male rat models of obesity,… read more here.
Keywords: treatment; zgn 440; hypothalamic obesity; excess weight ... See more keywords
A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity
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DOI: 10.1210/jendso/bvad037
Abstract: Abstract Context Hypothalamic obesity is a rare, treatment-resistant form of obesity. In preliminary studies, the hypothalamic hormone oxytocin (OXT) has shown promise as a potential weight loss therapy. Objective To determine whether 8 weeks of… read more here.
Keywords: hypothalamic obesity; pilot; placebo; obesity ... See more keywords
Dextroamphetamine Treatment in Children With Hypothalamic Obesity
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DOI: 10.3389/fendo.2022.845937
Abstract: Introduction Hypothalamic obesity (HO) in children has severe health consequences. Lifestyle interventions are mostly insufficient and currently no drug treatment is approved for children with HO. Amphetamines are known for their stimulant side-effect on resting… read more here.
Keywords: hypothalamic obesity; energy; bmi sds; dextroamphetamine treatment ... See more keywords
Treatment of Acquired Hypothalamic Obesity: Now and the Future
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DOI: 10.3389/fendo.2022.846880
Abstract: The hypothalamus is the centre of neuroendocrine regulation of energy homeostasis and appetite. Maldevelopment of, or damage to, the key hypothalamic nuclei disrupts the coordinated balance between energy intake and expenditure leading, to rapid and… read more here.
Keywords: acquired hypothalamic; weight loss; obesity; energy ... See more keywords