Effects of tamoxifen on neuronal morphology, connectivity and biochemistry of hypothalamic ventromedial neurons: Impact on the modulators of sexual behavior
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DOI: 10.1016/j.nbd.2017.09.009
Abstract: Tamoxifen (TAM) is a selective estrogen receptor modulator, widely used in the treatment and prevention of estrogen-dependent breast cancer. Although with great clinical results, women on TAM therapy still report several side effects, such as… read more here.
Keywords: biochemistry; connectivity; sexual behavior; effects tamoxifen ... See more keywords
Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity
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DOI: 10.2337/db16-1558
Abstract: The Lin28a/Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation. However, its central function remains unclear. Here we found that Lin28a is highly expressed in the hypothalamus compared with peripheral… read more here.
Keywords: metabolism; diet induced; lin28a; mice ... See more keywords
Distinct Neuronal Projections From the Hypothalamic Ventromedial Nucleus Mediate Glycemic and Behavioral Effects
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DOI: 10.2337/db18-0380
Abstract: The hypothalamic ventromedial nucleus (VMN) is implicated both in autonomic control of blood glucose and in behaviors including fear and aggression, but whether these divergent effects involve the same or distinct neuronal subsets and their… read more here.
Keywords: distinct neuronal; ventromedial nucleus; activation; vmnnos1 ... See more keywords