Evaluation of hypothalamus‐pituitary‐thyroid axis function by chronic perchlorate exposure in male rats
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Toxicology"
DOI: 10.1002/tox.22509
Abstract: Perchlorate is a widespread endocrine disruptor that was previously correlated with increased serum TSH levels and decreased thyroid hormones production both in animals and humans. Even so, the regulation of gene/protein expression in the hypothalamus,… read more here.
Keywords: pituitary thyroid; hypothalamus pituitary; perchlorate; perchlorate exposure ... See more keywords
Effect of Intracerebroventricular Administration of Apelin-13 on the Hypothalamus–Pituitary–Thyroid Axis and Peripheral Uncoupling Proteins
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-017-9638-9
Abstract: Apelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus–pituitary–thyroid (HPT) axis and mechanism of action… read more here.
Keywords: apelin; group; hpt axis; hypothalamus pituitary ... See more keywords
Low-dose ACTH test for evaluation of hypothalamus–pituitary–adrenal axis preoperatively and 3-month follow-up in non-functioning pituitary adenomas
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01292-8
Abstract: Background Peri-operative glucocorticoids are routinely administered to patients undergoing trans-sphenoidal surgery for non-functional pituitary adenomas (NFPA) irrespective of hypothalamus–pituitary–adrenal (HPA) axis status. Purpose Evaluation of HPA axis before and 12 weeks after endoscopic trans-sphenoidal adenomectomy… read more here.
Keywords: cortisol; hypocortisolism; pituitary adenomas; hypothalamus pituitary ... See more keywords
The Emerging Key Role of Klotho in the Hypothalamus–Pituitary–Ovarian Axis
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00277-5
Abstract: The hypothalamus–pituitary–ovary axis is the most important system for regulating female reproductive endocrine function. Its dysfunction would lead to the abnormal secretion of gonadotropin-releasing hormone, follicle-stimulating hormone, or luteinizing hormone, and eventually result in the… read more here.
Keywords: axis; hypothalamus pituitary; klotho; key role ... See more keywords
Frontiers in endocrine disruption: Impacts of organotin on the hypothalamus-pituitary-thyroid axis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.07.038
Abstract: Endocrine disruptors (EDs), chemical substances widely used in industry and ubiquitously distributed in the environment, are able to interfere with the synthesis, release, transport, metabolism, receptor binding, action, or elimination of endogenous hormones. EDs affect… read more here.
Keywords: disruption; thyroid axis; hypothalamus pituitary; pituitary thyroid ... See more keywords
The role of the hypothalamus and pituitary epigenomes in central activation of the reproductive axis at puberty
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111031
Abstract: Puberty is programmed through a multifactorial gene network which works to activate the pulsatile secretion of the gonadotropin releasing hormone (GnRH), and subsequently elevate circulating levels of the pituitary gonadotropins that stimulate gonadal activity. Although… read more here.
Keywords: role hypothalamus; hypothalamus pituitary; puberty; activation ... See more keywords
Genome-wide DNA methylation analysis of the porcine hypothalamus-pituitary-ovary axis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04603-x
Abstract: Previous studies have suggested that DNA methylation in both CpG and CpH (where H = C, T or A) contexts plays a critical role in biological functions of different tissues. However, the genome-wide DNA methylation patterns of… read more here.
Keywords: genome wide; methylation; hypothalamus pituitary; wide dna ... See more keywords
Icariin inhibits inflammation via immunomodulation of the cutaneous hypothalamus–pituitary–adrenal axis in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13735
Abstract: Dysfunction of skin steroidogenesis plays an important role in inflammatory skin diseases. We previously carried out an animal study which showed that icariin could inhibit the inflammation of atopic dermatitis by regulating the cutaneous hypothalamus–pituitary–adrenal… read more here.
Keywords: hypothalamus pituitary; cutaneous hypothalamus; adrenal axis; pituitary adrenal ... See more keywords
Corticotroph isolation from Pomc‐eGFP mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid‐induced suppression of the hypothalamus–pituitary–adrenal axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13165
Abstract: Glucocorticoids (GC) are prescribed for periods > 3 months to 1%–3% of the UK population; 10%–50% of these patients develop hypothalamus‐pituitary–adrenal (HPA) axis suppression, which may last over 6 months and is associated with morbidity and… read more here.
Keywords: dex; pomc egfp; hypothalamus pituitary; suppression ... See more keywords
The immediate effects of weaning stress on the hypothalamus-pituitary-adrenal alteration of newly weaned piglets.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of animal physiology and animal nutrition"
DOI: 10.1111/jpn.13104
Abstract: This study was conducted to examine the effects of weaning stress on gene expression of specific markers in hypothalamus-pituitary-adrenal (HPA) axis and neuronal activity in the newly weaned piglets. Twelve 28-days-old, newly weaned crossbred (Landrace × Yorkshire × Duroc)… read more here.
Keywords: newly weaned; effects weaning; hypothalamus pituitary; pituitary adrenal ... See more keywords
Beta-hydroxybutyrate infusion identifies acutely differentially expressed genes related to metabolism and reproduction in the hypothalamus and pituitary of castrated male sheep.
Sign Up to like & getrecommendations! Published in 2018 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00104.2017
Abstract: To identify molecular pathways that couple metabolic imbalances and reproduction, we randomly assigned 10 castrated male sheep to be centrally injected into the lateral ventricle through intracerebroventricular cannulas with 1 ml of β-hydroxybutyric acid sodium… read more here.
Keywords: male sheep; reproduction; castrated male; hypothalamus pituitary ... See more keywords