Hypothesis-Driven Palladium-Catalyzed Transformations for the Construction of New Molecular Architectures.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical record"
DOI: 10.1002/tcr.202100095
Abstract: The development of new synthetic protocols to access diverse molecular scaffolds from readily available starting compounds is of significance in both academia and industry. Towards this, the catalysis by transition metals has been employed as… read more here.
Keywords: transformations construction; driven palladium; hypothesis driven; palladium catalyzed ... See more keywords
Enabling the hypothesis-driven prioritization of ligand candidates in big databases: Screenlamp and its application to GPCR inhibitor discovery for invasive species control
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-018-0100-7
Abstract: While the advantage of screening vast databases of molecules to cover greater molecular diversity is often mentioned, in reality, only a few studies have been published demonstrating inhibitor discovery by screening more than a million… read more here.
Keywords: species control; invasive species; hypothesis driven; discovery ... See more keywords
Are microbiome studies ready for hypothesis-driven research?
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2018.07.002
Abstract: Hypothesis-driven research has led to many scientific advances, but hypotheses cannot be tested in isolation: rather, they require a framework of aggregated scientific knowledge to allow questions to be posed meaningfully. This framework is largely… read more here.
Keywords: driven research; hypothesis driven; microbiome studies; studies ready ... See more keywords
Hypothesis-driven probabilistic modelling enables a principled perspective of genomic compartments
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1258
Abstract: The Hi-C method has revolutionized the study of genome organization, yet interpretation of Hi-C interaction frequency maps remains a major challenge. Genomic compartments are a checkered Hi-C interaction pattern suggested to represent the partitioning of… read more here.
Keywords: interaction; probabilistic modelling; genomic compartments; driven probabilistic ... See more keywords
Methodological advances for hypothesis‐driven ethnobiology
Sign Up to like & getrecommendations! Published in 2021 at "Biological Reviews"
DOI: 10.1111/brv.12752
Abstract: Ethnobiology as a discipline has evolved increasingly to embrace theory‐inspired and hypothesis‐driven approaches to study why and how local people choose plants and animals they interact with and use for their livelihood. However, testing complex… read more here.
Keywords: hypothesis driven; modelling; methodological advances; ethnobiology ... See more keywords
Recovering Critical Curriculum: Hypothesis-Driven Physical Examination as a Method to Increase Clinical Skills Teaching When Bedside Teaching Remains Limited
Sign Up to like & getrecommendations! Published in 2021 at "Southern Medical Journal"
DOI: 10.14423/smj.0000000000001203
Abstract: Medical students have re-entered their clinical training in a milieu that is vastly different from the one familiar to us. The coronavirus disease 2019 (COVID-19) pandemic shifted vital curriculum into the virtual setting; however, some… read more here.
Keywords: examination; bedside teaching; driven physical; curriculum ... See more keywords
Glioblastoma and the search for non-hypothesis driven combination therapeutics in academia
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1075559
Abstract: Glioblastoma (GBM) remains a cancer of high unmet clinical need. Current standard of care for GBM, consisting of maximal surgical resection, followed by ionisation radiation (IR) plus concomitant and adjuvant temozolomide (TMZ), provides less than… read more here.
Keywords: search non; glioblastoma search; non hypothesis; combination ... See more keywords