A novel hypothesis-generating approach for detecting phenotypic associations using epigenetic data
Sign Up to like & getrecommendations! Published in 2024 at "Epigenomics"
DOI: 10.1080/17501911.2024.2366157
Abstract: Background: Hypotheses about what phenotypes to include in causal analyses (that in turn can have clinical and policy implications) can be guided by hypothesis-free approaches, leveraging the epigenome for example. Materials & methods: Minimally adjusted… read more here.
Keywords: novel hypothesis; hypothesis generating; generating approach; hypothesis ... See more keywords
Hypothesis-generating evaluation of multi-armoured oncolytic HSV-1 (VG161) in intrahepatic cholangiocarcinoma: pooled insights from multicentre studies
Sign Up to like & getrecommendations! Published in 2025 at "Gut"
DOI: 10.1136/gutjnl-2025-335904
Abstract: Background Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited treatment options and poor prognosis, especially for patients who failed standard therapies. Objective To explore the safety, efficacy and immunological mechanisms of the novel… read more here.
Keywords: hypothesis generating; intrahepatic cholangiocarcinoma; evaluation multi; vg161 ... See more keywords
The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1532325
Abstract: Background Epitranscriptomics, with m6A as the most prevalent in mammals, is a novel treatment target for inflammatory diseases, including cardiovascular diseases. However, little is known about m6A RNA-regulation during myocardial infarction (MI). Methods In this… read more here.
Keywords: m6a; hypothesis generating; assail trial; sub study ... See more keywords
Is Cycling Practice Related to Men’s Pelvic Floor Dysfunctions? A Hypothesis-Generating Observational Study
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph18041923
Abstract: Background: There is a lack of consensus with regards to the consequences of cycling practice on urogenital and sexual problems in men. The aim of the study was to analyse the relationship between intensity of… read more here.
Keywords: years cycling; study; hypothesis generating; cycling practice ... See more keywords