Hypoxanthine phosphoribosyltransferase (HPRT)‐deficiency is associated with impaired fertility in the female rat
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23413
Abstract: The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that… read more here.
Keywords: phosphoribosyltransferase hprt; hypoxanthine phosphoribosyltransferase; hprt deficiency; hypoxanthine ... See more keywords
A Simple and Cost-effective Microfluidic Paper-Based Biosensor Analytical Device and its Application for Hypoxanthine Detection in Meat Samples
Sign Up to like & getrecommendations! Published in 2019 at "Food Analytical Methods"
DOI: 10.1007/s12161-019-01626-0
Abstract: In this paper, we combined lab-on-paper technology with biosensor techniques to fabricate a new analytical tool for hypoxanthine detection. The combination of these two technologies produces a quick, selective, and cost-effective analytical metrology for detection… read more here.
Keywords: meat samples; paper; hypoxanthine; hypoxanthine detection ... See more keywords
Application of TMAH thermochemolysis to the detection of nucleobases: Application to the MOMA and SAM space experiment.
Sign Up to like & getrecommendations! Published in 2019 at "Talanta"
DOI: 10.1016/j.talanta.2019.06.076
Abstract: Thermochemolysis of seven nucleobases-adenine, thymine, uracil, cytosine, guanine, xanthine, and hypoxanthine-in tetramethylammonium hydroxide (TMAH) was studied individually by pyrolysis gas chromatography mass spectrometry in the frame of the Mars surface exploration. The analyses were performed… read more here.
Keywords: application; tmah; cytosine; thermochemolysis ... See more keywords
Rodent Skeletal Muscle Metabolomic Changes Associated With Static Cold Storage.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.01.055
Abstract: OBJECTIVE The aim of this study was to evaluate the impact of static cold storage preservation on skeletal muscle metabolism using a rodent model. METHODS Sixteen male Lewis rats (250 ± 25 g) were distributed… read more here.
Keywords: static cold; skeletal muscle; storage; cold storage ... See more keywords
Highly efficient biosynthesis of hypoxanthine in Escherichia coli and transcriptome-based analysis of the purine metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.9b00396
Abstract: Nucleosides and purine analogs have multiple functions in cell physiology, food additives, and pharmaceuticals, and some are produced on a large scale using different microorganisms. However, biosynthesis of purines is still lacking. In the present… read more here.
Keywords: biosynthesis; hypoxanthine; escherichia coli; analysis ... See more keywords
Assessment of key plasma metabolites in combat casualties
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001277
Abstract: BACKGROUND Previous studies have indicated that hemorrhagic shock and injury cause significant early changes in metabolism. Recently, global changes in metabolism have been described using metabolomics in animal models and civilian trauma. We evaluated metabolic… read more here.
Keywords: hypoxanthine; injury severity; combat; combat injury ... See more keywords
POS1128 COMBINATION TREATMENT OF AR882, A NEW URAT1 INHIBITOR, AND XANTHINE OXIDASE INHIBITORS ALLOPURINOL OR FEBUXOSTAT: EFFECT ON URIC ACID, HYPOXANTHINE AND XANTHINE IN PLASMA OR SERUM AND URINE
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.1215
Abstract: Xanthine oxidase inhibitors (XOI) are commonly used as urate lowering therapy (ULT) for the treatment of gout. Allopurinol, the first-line treatment, demonstrates low response rate (< 40%), defined as serum urate (sUA) lowering effect below… read more here.
Keywords: allopurinol febuxostat; combination; xanthine; treatment ... See more keywords