FGF11 induced by hypoxia interacts with HIF‐1α and enhances its stability
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12547
Abstract: Fibroblast growth factor 11 (FGF11) is an intracellular FGF. Although induction of FGF11 by hypoxia has been observed in several cell types, the molecular function of FGF11 is not clearly understood yet. Here, we investigated… read more here.
Keywords: hif; fgf11 hypoxia; hypoxia; stability ... See more keywords
Mitochondrial ferritin expression in human macrophages is facilitated by thrombin‐mediated cleavage under hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14545
Abstract: Ferritins are iron storage proteins, which maintain cellular iron homeostasis. Among these proteins, the ferritin heavy chain is well characterized, but the regulatory principles of mitochondrial ferritin (FTMT) remain elusive. FTMT appears to be cleaved… read more here.
Keywords: cleavage; mitochondrial ferritin; expression; hypoxia ... See more keywords
Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin‐knockout mice
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12587
Abstract: High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein‐coupled receptor APJ and has possible roles in energy… read more here.
Keywords: hypoxia; metabolism; hypoxia exposure; mice ... See more keywords
Oxygen‐Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202102234
Abstract: Solid tumors are protected from antitumor immune responses due to their hypoxic microenvironments. Weakening hypoxia‐driven immunosuppression by hyperoxic breathing of 60% oxygen has shown to be effective in unleashing antitumor immune cells against solid tumors.… read more here.
Keywords: cell mediated; generating cryogels; hypoxic tumors; oxygen generating ... See more keywords
Pd@Au Bimetallic Nanoplates Decorated Mesoporous MnO2 for Synergistic Nucleus-Targeted NIR-II Photothermal and Hypoxia-Relieved Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201901528
Abstract: Bimetallic nanoparticles have received considerable attention owing to synergistic effect and their multifunctionality. Herein, new multifunctional Pd@Au bimetallic nanoplates decorated hollow mesoporous MnO2 nanoplates (H-MnO2 ) are demonstrated for achieving not only nucleus-targeted NIR-II photothermal… read more here.
Keywords: nucleus targeted; hypoxia; nanoplates decorated; mesoporous mno2 ... See more keywords
Outersphere Approach to Increasing the Persistance of Oxygen-Sensitive Europium(II)-Containing Contrast Agents for Magnetic Resonance Imaging with Perfluorocarbon Nanoemulsions toward Imaging of Hypoxia.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203209
Abstract: Radiographic mapping of hypoxia is needed to study a wide range of diseases. Complexes of EuII are a promising class of molecules to fit this need, but they are generally limited by their rapid oxidation… read more here.
Keywords: persistance oxygen; approach increasing; outersphere approach; hypoxia ... See more keywords
Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300089
Abstract: Hypoxia is a typical feature of most solid tumors and has important effects on tumor cells' proliferation, invasion, and metastasis. This is the key factor that leads to poor efficacy of different kinds of therapy… read more here.
Keywords: tumor hypoxia; tumor; hypoxia; strategy ... See more keywords
A "Chase and Block" Strategy for Enhanced Cancer Therapy with Hypoxia-Promoted Photodynamic Therapy and Autophagy Inhibition Based on Upconversion Nanocomposites.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202301087
Abstract: The combination of hypoxia-promoted photodynamic therapy (PDT) and autophagy modulation has shown strong potential in the treatment of hypoxic tumors. However, there are very few reports on hypoxia-enhanced photosensitizers with multi-band emitted upconversion nanoparticles (UCNPs)… read more here.
Keywords: upconversion; therapy; hypoxia; hypoxia promoted ... See more keywords
An Activity‐Based Photosensitizer to Reverse Hypoxia and Oxidative Resistance for Tumor Photodynamic Eradication
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202206659
Abstract: Photodynamic therapy (PDT) has been a well‐accepted clinical treatment for malignant tumors owing to its noninvasiveness and high spatiotemporal selectivity. However, the treatment outcome of current PDT applications is hindered by hypoxia and intracellular oxidative… read more here.
Keywords: oxidative resistance; hypoxia; based photosensitizer; activity ... See more keywords
Proton‐Driven Transformable 1O2‐Nanotrap for Dark and Hypoxia Tolerant Photodynamic Therapy
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DOI: 10.1002/advs.202200128
Abstract: Despite the clinical potential, photodynamic therapy (PDT) relying on singlet oxygen (1O2) generation is severely limited by tumor hypoxia and endosomal entrapment. Herein, a proton‐driven transformable 1O2‐nanotrap (ANBDP NPs) with endosomal escape capability is presented… read more here.
Keywords: 1o2 nanotrap; hypoxia; photodynamic therapy; proton driven ... See more keywords
Hypoxia‐Induced FUS–circTBC1D14 Stress Granules Promote Autophagy in TNBC
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204988
Abstract: Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that is suggested to be associated with hypoxia. This study is the first to identify a novel circular RNA (circRNA), circTBC1D14, whose expression… read more here.
Keywords: stress granules; fus circtbc1d14; hypoxia; tnbc ... See more keywords