Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin‐knockout mice
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DOI: 10.1002/2211-5463.12587
Abstract: High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein‐coupled receptor APJ and has possible roles in energy… read more here.
Keywords: hypoxia; metabolism; hypoxia exposure; mice ... See more keywords
Variable coastal hypoxia exposure and drivers across the southern California Current
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DOI: 10.1038/s41598-021-89928-4
Abstract: Declining oxygen is one of the most drastic changes in the ocean, and this trend is expected to worsen under future climate change scenarios. Spatial variability in dissolved oxygen dynamics and hypoxia exposures can drive… read more here.
Keywords: california current; california; variability; hypoxia exposure ... See more keywords
Arachidonic Acid Metabolism Pathway Is Not Only Dominant in Metabolic Modulation but Associated With Phenotypic Variation After Acute Hypoxia Exposure
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DOI: 10.3389/fphys.2018.00236
Abstract: Background: The modulation of arachidonic acid (AA) metabolism pathway is identified in metabolic alterations after hypoxia exposure, but its biological function is controversial. We aimed at integrating plasma metabolomic and transcriptomic approaches to systematically explore… read more here.
Keywords: metabolism pathway; acid metabolism; metabolism; hypoxia exposure ... See more keywords
Nodal induced by hypoxia exposure contributes to dacarbazine resistance and the maintenance of stemness in melanoma cancer stem‑like cells.
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DOI: 10.3892/or.2018.6387
Abstract: Nodal signaling has a critical role in the processes of embryogenesis and is necessary for maintaining cell stemness. However, its upregulation in melanoma is positively correlated with malignant potential, including cancer progression, metastasis and recurrence,… read more here.
Keywords: melanoma; dacarbazine resistance; hypoxia exposure; cancer ... See more keywords