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Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21073-x
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and typically fatal lung disease with a very low survival rate. Excess accumulation of fibroblasts, myofibroblasts and extracellular matrix creates hypoxic conditions within the lungs, causing asphyxiation.…
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Keywords:
hif;
fibroblast proliferation;
proliferation;
hypoxia induces ... See more keywords
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Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2061967
Abstract: Abstract Uterine leiomyomas, the most common tumors of the female reproductive system, are known to have a hypoxic microenvironment. However, the role of such environment in leiomyoma pathobiology remains unknown. The objective was to determine…
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Keywords:
leiomyoma;
leiomyoma cells;
proliferation;
hypoxia induces ... See more keywords
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Published in 2023 at "Royal Society Open Science"
DOI: 10.1098/rsos.220992
Abstract: Mutations in polycystin-1 which is encoded by the PKD1 gene are the main causes for the development of autosomal dominant polycystic kidney disease. However, only little is known about the physiological function of polycystin-1 and…
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Keywords:
hypoxia induces;
expression;
hypoxia;
induces polycystin ... See more keywords
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Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1049698
Abstract: Blood-brain-barrier permeability is regulated by endothelial junctional proteins and is vital in limiting access to and from the blood to the CNS. When stressed, several cells, including endothelial cells, can release nucleotides like ATP and…
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Keywords:
endothelial barrier;
barrier function;
function;
endothelial cells ... See more keywords
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Published in 2023 at "Theranostics"
DOI: 10.7150/thno.78736
Abstract: M2 macrophage-mediated tissue repair plays an important role in acute myocardial infarction (AMI). Additionally, VSIG4, which is mainly expressed on tissue-resident and M2 macrophages, is crucial for the regulation of immune homeostasis; however, its effects…
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Keywords:
vsig4;
hypoxia induces;
myocardial infarction;
ami ... See more keywords