Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling
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DOI: 10.1038/s41598-018-21073-x
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and typically fatal lung disease with a very low survival rate. Excess accumulation of fibroblasts, myofibroblasts and extracellular matrix creates hypoxic conditions within the lungs, causing asphyxiation.… read more here.
Keywords: hif; fibroblast proliferation; proliferation; hypoxia induces ... See more keywords
Hypoxia induces proliferation via NOX4-Mediated oxidative stress and TGF-β3 signaling in uterine leiomyoma cells
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DOI: 10.1080/10715762.2022.2061967
Abstract: Abstract Uterine leiomyomas, the most common tumors of the female reproductive system, are known to have a hypoxic microenvironment. However, the role of such environment in leiomyoma pathobiology remains unknown. The objective was to determine… read more here.
Keywords: leiomyoma; leiomyoma cells; proliferation; hypoxia induces ... See more keywords
Hypoxia induces polycystin-1 expression in the renal epithelium
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DOI: 10.1098/rsos.220992
Abstract: Mutations in polycystin-1 which is encoded by the PKD1 gene are the main causes for the development of autosomal dominant polycystic kidney disease. However, only little is known about the physiological function of polycystin-1 and… read more here.
Keywords: hypoxia induces; expression; hypoxia; induces polycystin ... See more keywords
Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1049698
Abstract: Blood-brain-barrier permeability is regulated by endothelial junctional proteins and is vital in limiting access to and from the blood to the CNS. When stressed, several cells, including endothelial cells, can release nucleotides like ATP and… read more here.
Keywords: endothelial barrier; barrier function; function; endothelial cells ... See more keywords
Hypoxia Induces M2 Macrophages to Express VSIG4 and Mediate Cardiac Fibrosis After Myocardial Infarction
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DOI: 10.7150/thno.78736
Abstract: M2 macrophage-mediated tissue repair plays an important role in acute myocardial infarction (AMI). Additionally, VSIG4, which is mainly expressed on tissue-resident and M2 macrophages, is crucial for the regulation of immune homeostasis; however, its effects… read more here.
Keywords: vsig4; hypoxia induces; myocardial infarction; ami ... See more keywords