Metabolic study of hypoxia-inducible factor stabilizers BAY 87-2243, MK-8617, and PT-2385 in equine liver microsomes for doping control.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3348
Abstract: A number of erythropoiesis stimulants are entering the final stage of clinical trials due to recent scientific progress in hypoxia-regulated erythropoiesis. Considering how erythropoiesis-stimulating compounds enhance the capacity of the organism to transport oxygen, they… read more here.
Keywords: 8617 2385; 2243 8617; bay 2243; hypoxia inducible ... See more keywords
Hypoxia‐Inducible Factor 1 Alpha–Mediated RelB/APOBEC3B Down‐regulation Allows Hepatitis B Virus Persistence
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31902
Abstract: Therapeutic strategies against HBV focus, among others, on the activation of the immune system to enable the infected host to eliminate HBV. Hypoxia‐inducible factor 1 alpha (HIF1α) stabilization has been associated with impaired immune responses.… read more here.
Keywords: factor alpha; inducible factor; hypoxia inducible;
Hypoxia‐Inducible Exosomes Facilitate Liver‐Tropic Premetastatic Niche in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32009
Abstract: Liver metastasis is a frequent occurrence in patients with colorectal cancer (CRC), with 15%‐25% of CRC patients having liver metastases at the time of initial diagnosis. Specifically, some regional‐stage patients with mild symptoms (stage 1… read more here.
Keywords: inducible exosomes; colorectal cancer; facilitate liver; exosomes facilitate ... See more keywords
The role of hypoxia‐inducible factor‐2 alpha in angiogenesis
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DOI: 10.1002/jcp.26805
Abstract: Angiogenesis is a key enabling feature of mammalian embryonic development and tumor progression, which provides oxygen and nutrients that are required for vessel growth and tumor cell growth, respectively. Hypoxia is a driver of this… read more here.
Keywords: angiogenesis; role hypoxia; inducible factor; factor alpha ... See more keywords
Oxidized low‐density lipoprotein suppresses mouse granulosa cell differentiation through disruption of the hypoxia‐inducible factor 1 pathway
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22933
Abstract: Obesity predisposes women to reproductive disorders. One symptom of obesity in women is higher levels of oxidized Low‐density lipoprotein (oxLDL) in serum and preovulatory follicles. The present study was designed to test the hypothesis that… read more here.
Keywords: oxidized low; density lipoprotein; inducible factor; low density ... See more keywords
Genetic Knockdown and Pharmacologic Inhibition of Hypoxia-Inducible Factor (HIF) Hydroxylases.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7665-2_1
Abstract: Reduced oxygen supply that does not satisfy tissue and cellular demand (hypoxia) regularly occurs both in health and disease. Hence, the capacity for cellular oxygen sensing is of vital importance for each cell to be… read more here.
Keywords: oxygen; hif; inhibition; factor ... See more keywords
Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1707-9
Abstract: Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain largely unclear. Recently, hyperglycemia-induced mitochondrial dysfunction and the generation of reactive oxygen… read more here.
Keywords: inducible factor; hif1; sensory neurons; hyperglycemia ... See more keywords
Hypoxia-inducible factor-1α in Antarctic notothenioids contains a polyglutamine and glutamic acid insert that varies in length with phylogeny
Sign Up to like & getrecommendations! Published in 2017 at "Polar Biology"
DOI: 10.1007/s00300-017-2164-6
Abstract: The long evolution of the Antarctic perciform suborder of Notothenioidei in the icy, oxygen-rich waters of the Southern Ocean may have reduced selective pressure to maintain a hypoxic response. To test this hypothesis, cDNA of… read more here.
Keywords: hif; amino acids; inducible factor; contains polyglutamine ... See more keywords
Hypoxia and hypoxia-inducible factors in neuroblastoma
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DOI: 10.1007/s00441-017-2701-1
Abstract: Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.… read more here.
Keywords: hif; hypoxia hypoxia; hif hif; inducible factors ... See more keywords
Hypoxia-inducible factor 1α from a high-altitude fish enhances cytoprotection and elevates nitric oxide production in hypoxic environment
Sign Up to like & getrecommendations! Published in 2019 at "Fish Physiology and Biochemistry"
DOI: 10.1007/s10695-019-00694-7
Abstract: Hypoxia-inducible factors (HIFs) are master transcription factor regulating hypoxic responses in vertebrates. Species of Schizothoracine, a sub-family of cyprinidae, are highly endemic to the hypoxic Qinghai-Tibetan Plateau (QTP). What roles the HIFs play in hypoxic… read more here.
Keywords: hif; nitric oxide; dobula; hypoxic ... See more keywords
Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2018.11.001
Abstract: Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A… read more here.
Keywords: chemotherapy; breast; cancer; inducible factors ... See more keywords