Sustained Release of Dexamethasone from Sulfobutyl Ether β-cyclodextrin Modified Self-Assembling Peptide Nanoscaffolds in a Perinatal Rat Model of Hypoxia-Ischemia.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900083
Abstract: Inflammation plays a critical role in the development of hypoxia-ischemia (HI) induced newborn brain damage. A localized, sustained delivery of dexamethasone (Dex) through an intracerebral injection could reduce the inflammatory response in the injured perinatal… read more here.
Keywords: hypoxia ischemia; dex; sbe rada; sulfobutyl ether ... See more keywords
Photonic Technology for In Vivo Monitoring of Hypoxia–Ischemia
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204834
Abstract: Surveillance of physiological parameters of newborns during delivery triggers medical decision‐making, can rescue life and health, and helps avoid unnecessary cesareans. Here, the development of a photonic technology for monitoring perinatal asphyxia is presented and… read more here.
Keywords: technology; technology vivo; photonic technology; hypoxia ischemia ... See more keywords
Concurrent decrease of brain white matter tracts' thicknesses and fractional anisotropy after antenatal hypoxia‐ischemia detected with tract‐based spatial statistics analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.25407
Abstract: To examine the extent of gray and white matter (WM) injury following global antenatal hypoxia‐ischemia (H‐I) and resulting in muscle hypertonia in newborns in a rabbit cerebral palsy model. read more here.
Keywords: hypoxia ischemia; antenatal hypoxia; white matter;
Sex‐dependent consequences of neonatal brain hypoxia‐ischemia in the rat
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23828
Abstract: Neonatal hypoxia‐ischemia (HI) is an important cause of neurological deficits in humans, and the Levine‐Rice model of experimental HI in the rat mimics the human brain lesion and the following sensory motor deficits and cognitive… read more here.
Keywords: sex dependent; brain; hypoxia ischemia; sex ... See more keywords
NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02496-6
Abstract: Brain photobiomodulation (PBM) is an innovative treatment for a variety of neurological conditions, including cerebral ischemia. However, the capability of PBM for ischemic stroke needs to be further explored and its mechanisms of action remain… read more here.
Keywords: nir laser; hypoxia ischemia; photobiomodulation; model ... See more keywords
Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia–ischemia
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.12.012
Abstract: Neonatal encephalopathy following hypoxia-ischemia (HI) is a major cause of long-term morbidity and mortality in children. Even though HI-induced neuroinflammation, involving infiltration of peripheral immune cells into the CNS has been associated with disease pathogenesis,… read more here.
Keywords: dynamics plasticity; hypoxia ischemia; neurodegeneration; neutrophil dynamics ... See more keywords
Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.113117
Abstract: Previous studies have shown that simvastatin (Sim) has neuroprotective effects in a neonatal model of hypoxia-ischemia (HI)-induced brain injury when administered before but not after HI, pointing to the preconditioning (PC)-like effects of the statin.… read more here.
Keywords: sirt1; induced brain; hypoxia ischemia; ischemia induced ... See more keywords
Differential glucose and beta-hydroxybutyrate metabolism confers an intrinsic neuroprotection to the immature brain in a rat model of neonatal hypoxia ischemia
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113317
Abstract: Neonatal hypoxia ischemia (HI) is the main cause of newborn mortality and morbidity. Preclinical studies have shown that the immature rat brain is more resilient to HI injury, suggesting innate mechanisms of neuroprotection. During neonatal… read more here.
Keywords: hypoxia ischemia; glucose beta; neonatal hypoxia; metabolism ... See more keywords
Pregnancy swimming prevents early brain mitochondrial dysfunction and causes sex-related long-term neuroprotection following neonatal hypoxia-ischemia in rats
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113623
Abstract: Neonatal hypoxia-ischemia (HI) is a major cause of cognitive impairments in infants. Antenatal strategies improving the intrauterine environment can have high impact decreasing pregnancy-derived intercurrences. Physical exercise alters the mother-fetus unity and has been shown… read more here.
Keywords: hypoxia ischemia; neonatal hypoxia; pregnancy swimming; dysfunction ... See more keywords
Galantamine administration reduces reactive astrogliosis and upregulates the anti-oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Developmental Neuroscience"
DOI: 10.1016/j.ijdevneu.2017.07.006
Abstract: Neonatal hypoxia ischemia (HI) plays a role in the etiology of several neurological pathologies and causes severe sequelae. Acetylcholine is a neurotransmitter in the central nervous system and cholinesterase inhibitors have demonstrated a positive action… read more here.
Keywords: hypoxia ischemia; neonatal hypoxia; galantamine; anti oxidant ... See more keywords
The role of SUMOylation in cerebral hypoxia and ischemia
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.03.011
Abstract: ABSTRACT The process of protein modification by adding or detaching small ubiquitin‐like modifiers (SUMO) proteins, called SUMOylation, contributes to the regulation of numerous processes in eukaryotic cells. SUMOylation also represents a key response and adaption… read more here.
Keywords: sumoylation; hypoxia ischemia; role sumoylation; sumoylation cerebral ... See more keywords