Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.07.009
Abstract: BACKGROUND Hypertension-induced microvascular brain injury is a major vascular contributor to cognitive impairment and dementia. We hypothesized that chronic hypoxia promotes the hyperphosphorylation of tau and cell death in an accelerated spontaneously hypertensive stroke prone… read more here.
Keywords: dorsolateral cortex; hyperphosphorylation; vascular dysfunction; hypoxia promotes ... See more keywords
Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.726153
Abstract: Phagocytosis, degranulation, and neutrophil extracellular traps (NETs) formation build the armory of neutrophils for the first line of defense against invading pathogens. All these processes are modulated by the microenvironment including tonicity, pH and oxygen… read more here.
Keywords: infarction; myocardial infarction; hypoxia promotes; neutrophil survival ... See more keywords
hCLOCK induction by hypoxia promotes inflammatory responses by activating the NF‑κB pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6127
Abstract: The expression and secretion of infla-mmation‑associated cytokines are induced by hypoxia. Circadian locomotor output cycles protein kaput (CLOCK) has previously been shown to activate the nuclear factor‑κB (NF‑κB) pathway, which is a key transcription factor… read more here.
Keywords: hclock induction; induction hypoxia; pathway; clock ... See more keywords