A General Hypoxia-Responsive Molecular Container for Tumor-Targeted Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.201908435
Abstract: Enhanced drug delivery can improve the therapeutic efficacy of drugs and help overcome side effects. However, many reported drug-delivery systems are too complex and irreproducible for practical use. In this work, the design of a… read more here.
Keywords: hypoxia responsive; molecular container; drug delivery; drug ... See more keywords
Hypoxia-Responsive Photosensitizer Targeting Dual Organelles for Photodynamic Therapy of Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205440
Abstract: Developing safe and precise image-guided photodynamic therapy is a challenge. In this study, the hypoxic properties of solid tumors are exploited to construct a hypoxia-responsive photosensitizer, TPA-Azo. Introducing the azo group into the photosensitizer TPA-BN… read more here.
Keywords: photosensitizer tpa; hypoxia responsive; photodynamic therapy; responsive photosensitizer ... See more keywords
Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120278
Abstract: Tumor hypoxia-responsive size-switchable nanosystems for precise delivery of drug into deep tumor show great prospects for killing cancer cells with high specificity and minimal invasiveness. However, the development of versatile nanosystems is still a challenge.… read more here.
Keywords: hypoxia responsive; copper metal; responsive copper; metal organic ... See more keywords
Hypoxia-responsive transgene expression system using RTP801 promoter and synthetic transactivator fused with oxygen-dependent degradation domain.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2017.02.012
Abstract: Precise control of gene expression using an artificial gene circuit is a major challenge in the application of synthetic biology. Here, we designed a hypoxia-responsive transgene expression system by combining a hypoxia-inducible RTP801 promoter and… read more here.
Keywords: hypoxia responsive; transactivator; expression; responsive transgene ... See more keywords
Light-Induced Hypoxia-Triggered Living Nanocarriers for Synergistic Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b03506
Abstract: Living drug delivery system has been proposed as new concept materials because it is able to communicate with biological system, sense subtle changes in body microenvironment caused by disease, and then make rapid response to… read more here.
Keywords: therapy; hypoxia responsive; light induced; hypoxia ... See more keywords
Enamine N-Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents
Sign Up to like & getrecommendations! Published in 2021 at "ACS Central Science"
DOI: 10.1021/acscentsci.0c01586
Abstract: Tumor hypoxia induces the large-scale adaptive reprogramming of cancer cells, promoting their transformation into highly invasive and metastatic species that lead to highly negative prognoses for cancer patients. We describe the synthesis and application of… read more here.
Keywords: hypoxia responsive; application; enamine oxide; synthesis application ... See more keywords
Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23196-7
Abstract: The integrity of the avascular nucleus pulposus (NP) phenotype plays a crucial role in the maintenance of intervertebral disc health. While advances have been made to define the molecular phenotype of healthy NP cells, the… read more here.
Keywords: hypoxia responsive; stress induced; expression; nucleus pulposus ... See more keywords
Hypoxia-responsive lncRNA G077640 promotes ESCC tumorigenesis via the H2AX-HIF1α-glycolysis axis.
Sign Up to like & getrecommendations! Published in 2023 at "Carcinogenesis"
DOI: 10.1093/carcin/bgad036
Abstract: Long noncoding RNAs (lncRNAs) contribute to esophageal squamous cell carcinoma (ESCC) progression, but the underlying mechanisms remain elusive. In this study, we verified a hitherto uncharacterized hypoxia-responsive lncRNA, G077640, which is upregulated in human ESCC… read more here.
Keywords: hypoxia responsive; g077640; hif1; responsive lncrna ... See more keywords
High-CO2/Hypoxia-Responsive Transcription Factors DkERF24 and DkWRKY1 Interact and Activate DkPDC2 Promoter1
Sign Up to like & getrecommendations! Published in 2019 at "Plant Physiology"
DOI: 10.1104/pp.18.01552
Abstract: Two high-CO2/hypoxia responsive transcription factors from persimmon fruit, DkERF24 and DkWRKY1, form a complex and synergistically transactivate the promoter of the hypoxia-responsive gene DkPDC2. Identification and functional characterization of hypoxia-responsive transcription factors is important for… read more here.
Keywords: transcription; hypoxia responsive; high co2; promoter ... See more keywords
Hypoxia-Responsive Molecular Probe Lighted up by Peptide Self-Assembly for Cancer Cell Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2022.3304
Abstract: Hypoxia is a characteristic feature of most solid tumors, which promotes the proliferation, metastasis, and invasion of tumors and stimulates the resistance of cancer treatments, leading to the serious consequences of tumor recurrence. The exploration… read more here.
Keywords: lighted peptide; hypoxia responsive; hypoxia; responsive molecular ... See more keywords
RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059371
Abstract: ABSTRACT Adaptive biological mechanisms to hypoxia are crucial to maintain oxygen homeostasis, especially in the brain. Pericytes, cells uniquely positioned at the blood-brain interface, respond fast to hypoxia by expressing regulator of G-protein signalling 5… read more here.
Keywords: role; brain; hypoxia; hypoxia responsive ... See more keywords