A General Hypoxia-Responsive Molecular Container for Tumor-Targeted Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.201908435
Abstract: Enhanced drug delivery can improve the therapeutic efficacy of drugs and help overcome side effects. However, many reported drug-delivery systems are too complex and irreproducible for practical use. In this work, the design of a… read more here.
Keywords: hypoxia responsive; molecular container; drug delivery; drug ... See more keywords
Hypoxia-Responsive Photosensitizer Targeting Dual Organelles for Photodynamic Therapy of Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205440
Abstract: Developing safe and precise image-guided photodynamic therapy is a challenge. In this study, the hypoxic properties of solid tumors are exploited to construct a hypoxia-responsive photosensitizer, TPA-Azo. Introducing the azo group into the photosensitizer TPA-BN… read more here.
Keywords: photosensitizer tpa; hypoxia responsive; photodynamic therapy; responsive photosensitizer ... See more keywords
Hypoxia-Responsive Covalent Organic Framework Nanoplatform for Breast-Cancer-Targeted Cocktail Immunotherapy via Triple Therapeutic Switch Mechanisms.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202407553
Abstract: Covalent organic frameworks (COFs), known for their exceptional in situ encapsulation and precise release capabilities, are emerging as pioneering drug delivery systems. This study introduces a hypoxia-responsive COF designed to encapsulate the chemotherapy drug gambogic… read more here.
Keywords: cancer; covalent organic; nanoplatform; triple therapeutic ... See more keywords
Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120278
Abstract: Tumor hypoxia-responsive size-switchable nanosystems for precise delivery of drug into deep tumor show great prospects for killing cancer cells with high specificity and minimal invasiveness. However, the development of versatile nanosystems is still a challenge.… read more here.
Keywords: hypoxia responsive; copper metal; responsive copper; metal organic ... See more keywords
Hypoxia-responsive transgene expression system using RTP801 promoter and synthetic transactivator fused with oxygen-dependent degradation domain.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2017.02.012
Abstract: Precise control of gene expression using an artificial gene circuit is a major challenge in the application of synthetic biology. Here, we designed a hypoxia-responsive transgene expression system by combining a hypoxia-inducible RTP801 promoter and… read more here.
Keywords: hypoxia responsive; transactivator; expression; responsive transgene ... See more keywords
Light-Induced Hypoxia-Triggered Living Nanocarriers for Synergistic Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b03506
Abstract: Living drug delivery system has been proposed as new concept materials because it is able to communicate with biological system, sense subtle changes in body microenvironment caused by disease, and then make rapid response to… read more here.
Keywords: therapy; hypoxia responsive; light induced; hypoxia ... See more keywords
Enamine N-Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents
Sign Up to like & getrecommendations! Published in 2021 at "ACS Central Science"
DOI: 10.1021/acscentsci.0c01586
Abstract: Tumor hypoxia induces the large-scale adaptive reprogramming of cancer cells, promoting their transformation into highly invasive and metastatic species that lead to highly negative prognoses for cancer patients. We describe the synthesis and application of… read more here.
Keywords: hypoxia responsive; application; enamine oxide; synthesis application ... See more keywords
Light-Activated Hypoxia-Responsive Nanoparticles for Photodynamic Chemotherapy
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.4c11283
Abstract: Hypoxia is a characteristic of solid tumors, and it significantly impedes cancer treatment. Here, we report light-activated hypoxia-responsive nanoparticles NPs-TPZ consisting of 5,10,5,20-tetrakis(4-aminophenyl)-porphine (TAPP) modified with four azobenzene groups, cyclodextrin (CD), and 3-aminobenzotriazine-1,4-di-N-oxide tirapazamine (TPZ)… read more here.
Keywords: light activated; photodynamic chemotherapy; activated hypoxia; responsive nanoparticles ... See more keywords
Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23196-7
Abstract: The integrity of the avascular nucleus pulposus (NP) phenotype plays a crucial role in the maintenance of intervertebral disc health. While advances have been made to define the molecular phenotype of healthy NP cells, the… read more here.
Keywords: hypoxia responsive; stress induced; expression; nucleus pulposus ... See more keywords
A hypoxia-targeting and hypoxia-responsive nano-probe for tumor detection and early diagnosis.
Sign Up to like & getrecommendations! Published in 2025 at "Biomaterials science"
DOI: 10.1039/d4bm01499e
Abstract: Accurate imaging of tumor hypoxia in vivo is critical for early cancer diagnosis and clinical outcomes, highlighting the great need for its detection specificity and sensitivity. In this report, we propose a probe (HTRNP) that… read more here.
Keywords: detection; hypoxia targeting; targeting hypoxia; hypoxia ... See more keywords
A hypoxia-responsive liquid metal-containing nanomaterial for cancer phototheranostics.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale"
DOI: 10.1039/d5nr01761k
Abstract: In this communication, we introduce a hypoxia-responsive liquid metal-containing nanomaterial, referred to as an LMNPs/HS-β-CD/TPE-2NHCOO-azo-TEG complex, for fluorescence imaging and photothermal ablation of tumor cells. This novel nanomaterial exhibits several intriguing properties, and its features… read more here.
Keywords: liquid metal; metal containing; responsive liquid; hypoxia responsive ... See more keywords