Sequential Ultrasound-Triggered and Hypoxia-Sensitive Nanoprodrug for Cascade Amplification of Sonochemotherapy.
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DOI: 10.1021/acsnano.1c09505
Abstract: Hypoxia, the typical and conspicuous characteristic of most solid tumors, worsens the tumor invasiveness and metastasis. Here, we engineered a sequential ultrasound (US)/hypoxia-sensitive sonochemotherapeutic nanoprodrug by initially synthesizing the hypoxia-activated azo bond-containing camptothecin (CPT) prodrug… read more here.
Keywords: sequential ultrasound; hypoxia sensitive; hypoxia; cpt2 azo ... See more keywords
A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans
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DOI: 10.1126/sciadv.ade1942
Abstract: In Tibetans, noncoding alleles in EPAS1—whose protein product hypoxia-inducible factor 2α (HIF-2α) drives the response to hypoxia—carry strong signatures of positive selection; however, their functional mechanism has not been systematically examined. Here, we report that… read more here.
Keywords: sensitive epas1; hypoxia sensitive; epas1; pleiotropic hypoxia ... See more keywords
Coassembly of hypoxia-sensitive macrocyclic amphiphiles and extracellular vesicles for targeted kidney injury imaging and therapy
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DOI: 10.1186/s12951-021-01192-w
Abstract: Background Hypoxia is a major contributor to global kidney diseases. Targeting hypoxia is a promising therapeutic option against both acute kidney injury and chronic kidney disease; however, an effective strategy that can achieve simultaneous targeted… read more here.
Keywords: kidney injury; hypoxia sensitive; targeted kidney; kidney ... See more keywords
A Hypoxia-Sensitive Drug Delivery System Constructed by Nitroimidazole and its Application in the Treatment of Hepatocellular Carcinoma
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DOI: 10.1208/s12249-022-02316-7
Abstract: Hypoxia is an important pathological phenomenon, and it can induce many tumor microenvironment changes, such as accumulations of intracellular lactic acid, decrease of tumor microenvironment pH value, and regulate a series of physiological and pathological… read more here.
Keywords: hepatocellular carcinoma; hypoxia sensitive; delivery system; drug delivery ... See more keywords