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Hypoxia Signaling in the Skeleton: Implications for Bone Health

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1 Published in 2019 at "Current Osteoporosis Reports"

DOI: 10.1007/s11914-019-00500-6

Abstract: Purpose of ReviewWe reviewed recent literature on oxygen sensing in osteogenic cells and its contribution to development of a skeletal phenotype, the coupling of osteogenesis with angiogenesis and integration of hypoxia into canonical Wnt signaling,… read more here.

Keywords: oxygen; skeleton implications; hypoxia signaling; implications bone ... See more keywords

Hypoxia signaling: Challenges and opportunities for cancer therapy.

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0 Published in 2021 at "Seminars in cancer biology"

DOI: 10.1016/j.semcancer.2021.10.002

Abstract: Hypoxia is arguably the first recognized cancer microenvironment hallmark and affects virtually all cellular populations present in tumors. During the past decades the complex adaptive cellular responses to oxygen deprivation have been largely elucidated, raising… read more here.

Keywords: hypoxia signaling; challenges opportunities; signaling challenges; hypoxia ... See more keywords

ONECUT2 is a driver of neuroendocrine prostate cancer

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1 Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-018-08133-6

Abstract: Neuroendocrine prostate cancer (NEPC), a lethal form of the disease, is characterized by loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, which results in resistance to AR-targeted therapy. Clinically, genomically and epigenetically, NEPC resembles… read more here.

Keywords: hypoxia; hypoxia signaling; neuroendocrine prostate; prostate cancer ... See more keywords

ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness

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1 Published in 2022 at "EMBO reports"

DOI: 10.15252/embr.202154042

Abstract: Aberrant activation of the hypoxia‐inducible transcription factor HIF‐1 and dysfunction of the tumor suppressor p53 have been reported to induce malignant phenotypes and therapy resistance of cancers. However, their mechanistic and functional relationship remains largely… read more here.

Keywords: hypoxia signaling; p53 deficiency; p53; zbtb2 ... See more keywords

VHL and Hypoxia Signaling: Beyond HIF in Cancer

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1 Published in 2018 at "Biomedicines"

DOI: 10.3390/biomedicines6010035

Abstract: Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC). Its regulatory pathway involves the activity of E3 ligase, which targets hypoxia inducible… read more here.

Keywords: hypoxia signaling; vhl; signaling beyond; vhl hypoxia ... See more keywords