Constructing Hypoxia-Tolerant and Host Tumor-Enriched Aggregation-Induced Emission Photosensitizer for Suppressing Malignant Tumors Relapse and Metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202203825
Abstract: Photodynamic immunotherapy is a promising treatment strategy that destroys primary tumors and inhibits the metastasis and relapse of distant tumors. As reactive oxygen species are an intermediary for triggering immune responses, photosensitizers (PSs) that can… read more here.
Keywords: metastasis; tumor; hypoxia tolerant; aggregation induced ... See more keywords
Increase of a hypoxia-tolerant fish, Harpadon nehereus (Synodontidae), as a result of ocean deoxygenation off southwestern China
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Biology of Fishes"
DOI: 10.1007/s10641-021-01130-7
Abstract: We report a sudden explosive rise in abundance off southeastern China of a fish species that is hypoxia-tolerant, Bombay duck (Harpadon nehereus, Family Synodontidae), belonging to an Order (the Aulopiformes) encompassing overwhelmingly deep-sea fishes, but… read more here.
Keywords: ocean deoxygenation; harpadon nehereus; synodontidae; hypoxia tolerant ... See more keywords
Mitochondrial mechanisms underlying tolerance to fluctuating oxygen conditions: Lessons from hypoxia-tolerant organisms.
Sign Up to like & getrecommendations! Published in 2019 at "Integrative and comparative biology"
DOI: 10.1093/icb/icz047
Abstract: Oxygen (O2) is essential for most metazoan life due to its central role in in mitochondrial oxidative phosphorylation (OXPHOS), which generates >90% of the cellular ATP. Oxygen fluctuations are an ultimate mitochondrial stressor resulting in… read more here.
Keywords: tolerance; tolerance fluctuating; hypoxia tolerant; fluctuating oxygen ... See more keywords
Evolution of Cytochrome c Oxidase in Hypoxia Tolerant Sculpins (Cottidae, Actinopterygii)
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msx179
Abstract: Vertebrate hypoxia tolerance can emerge from modifications to the oxygen (O2) transport cascade, but whether there is adaptive variation to O2 binding at the terminus of this cascade, mitochondrial cytochrome c oxidase (COX), is not… read more here.
Keywords: cytochrome oxidase; sculpins cottidae; hypoxia tolerant; cox ... See more keywords
Low Intensity Focused Ultrasound Ignited “Deep-Penetration Nanobomb” (DPNB) for Tetramodal Imaging Guided Hypoxia-Tolerant Sonodynamic Therapy Against Hypoxic Tumors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s361648
Abstract: Background Sonodynamic therapy (SDT) has been regarded as a novel therapeutic modality for killing tumors. However, the hypoxic tumor microenvironment, especially deep-seated tumors distant from blood vessels, severely restricts therapeutic efficacy due to the oxygen-dependent… read more here.
Keywords: hypoxia tolerant; hypoxic tumors; intensity focused; hypoxic ... See more keywords
Comprehensive Analysis of 13C6 Glucose Fate in the Hypoxia-Tolerant Blind Mole Rat Skin Fibroblasts
Sign Up to like & getrecommendations! Published in 2021 at "Metabolites"
DOI: 10.3390/metabo11110734
Abstract: The bioenergetics of the vast majority of terrestrial mammals evolved to consuming glucose (Glc) for energy production under regular atmosphere (about 21% oxygen). However, some vertebrate species, such as aquatic turtles, seals, naked mole rat,… read more here.
Keywords: hypoxia tolerant; mole rat; spalax cells; blind mole ... See more keywords