A Concerted Redox‐ and Light‐Activated Agent for Controlled Multimodal Therapy against Hypoxic Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210363
Abstract: Hypoxia represents a remarkably exploitable target for cancer therapy, is encountered only in solid human tumors, and is highly associated with cancer resistance and recurrence. Here, a hypoxia‐activated mitochondria‐accumulated Ru(II) polypyridyl prodrug functionalized with conjugated… read more here.
Keywords: cancer; controlled multimodal; agent; hypoxic ... See more keywords
Burning material behaviour in hypoxic environments: An experimental study examining a representative storage arrangement of acrylonitrile butadiene styrene, polyethylene bubble wrap, and cardboard layers as a composite system
Sign Up to like & getrecommendations! Published in 2021 at "Fire and Materials"
DOI: 10.1002/fam.3002
Abstract: Cone calorimeter and controlled atmosphere cone calorimeter experiments were conducted on various samples. The intent of the tests was to examine the behavior of uniform and composite samples in a range of thicknesses, irradiances, and… read more here.
Keywords: acrylonitrile butadiene; butadiene styrene; cardboard; arrangement ... See more keywords
Treatment with hypoxia‐mimetics protects cultured rat Schwann cells against oxidative stress‐induced cell death
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24019
Abstract: Schwann cell (SC) grafts promote axon regeneration in the injured spinal cord, but transplant efficacy is diminished by a high death rate in the first 2–3 days postimplantation. Both hypoxic preconditioning and pharmacological induction of the… read more here.
Keywords: hif; death; hypoxic; hypoxia ... See more keywords
Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR‐338‐3p/PKM2 Axis Under Hypoxic Stress
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30671
Abstract: Glucose metabolism reprogramming, which is a well‐established characteristic of multiple cancers, demands a higher rate of glycolysis to meet the increasing demands for macromolecular synthesis and to maintain rapid proliferation in a hypoxic environment. However,… read more here.
Keywords: hcc; glycolysis; circmat2b; rna ... See more keywords
The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26247
Abstract: Neuroblastoma (NB) is a highly malignant pediatric solid tumor where a hypoxic signature correlates with unfavorable patient outcome. The hypoxia‐inducible factor (HIF)‐1α plays an important role in NB progression, contributing to cell proliferation and invasiveness.… read more here.
Keywords: hif; cell survival; rai; physiology ... See more keywords
Impact of l‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12221
Abstract: Abstract Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l‐arginine precursor, l‐citrulline, improves NO signaling and has therapeutic potential in PH. However, there is evidence that l‐citrulline might increase… read more here.
Keywords: arginase activity; hypoxic; nitric oxide; citrulline ... See more keywords
Hypoxic re-exposure retains hematological but not performance adaptations post-altitude training.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of applied physiology"
DOI: 10.1007/s00421-020-04589-x
Abstract: PURPOSE To test the hypothesis that hypoxic re-exposure after return from natural altitude training is beneficial in retaining hematological and performance adaptations. METHODS Eighteen mixed martial art fighters completed a 3-weeks natural altitude training camp… read more here.
Keywords: exposure; performance; hypoxic; day ... See more keywords
Sex-Related Features of the Reactions of Microcirculation Parameters in Symmetrical Areas of the Human Head to Hypoxic Exposure.
Sign Up to like & getrecommendations! Published in 2022 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-022-05425-2
Abstract: We studied sex-related features of the microcirculation response of symmetrical areas of the human head to hypoxic loads. In 20 healthy volunteers (10 male and 10 female), short-term hypoxia was modeled using the ReOxy Cardio… read more here.
Keywords: sex related; hypoxic; areas human; microcirculation ... See more keywords
Hypoxia-inducible factor 1α from a high-altitude fish enhances cytoprotection and elevates nitric oxide production in hypoxic environment
Sign Up to like & getrecommendations! Published in 2019 at "Fish Physiology and Biochemistry"
DOI: 10.1007/s10695-019-00694-7
Abstract: Hypoxia-inducible factors (HIFs) are master transcription factor regulating hypoxic responses in vertebrates. Species of Schizothoracine, a sub-family of cyprinidae, are highly endemic to the hypoxic Qinghai-Tibetan Plateau (QTP). What roles the HIFs play in hypoxic… read more here.
Keywords: hif; nitric oxide; dobula; hypoxic ... See more keywords
MicroRNA regulation in hypoxic environments: differential expression of microRNAs in the liver of largemouth bass (Micropterus salmoides).
Sign Up to like & getrecommendations! Published in 2020 at "Fish physiology and biochemistry"
DOI: 10.1007/s10695-020-00877-7
Abstract: Environmental changes in intensive aquaculture commonly lead to hypoxic stress for cultured largemouth bass (Micropterus salmoides). To better to understand the hypoxic stress response mechanisms, the miRNA expression profiles of the livers of largemouth bass… read more here.
Keywords: mir; largemouth bass; stress; expression ... See more keywords
Matrix regeneration proteins in the hypoxia-triggered exosomes of shoulder tenocytes and adipose-derived mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03669-7
Abstract: Regenerative functions of exosomes rely on their contents which are influenced by pathological stimuli, including hypoxia, in rotator cuff tendon injuries (RCTI). The hypoxic environment triggers tenocytes and adjacent adipose-derived mesenchymal stem cells (ADMSCs) to… read more here.
Keywords: derived mesenchymal; hypoxic; stem cells; adipose derived ... See more keywords