Cardiovascular Risk Through Hypoxic Burden in Children With Sleep Apnea
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.38744
Abstract: Key Points Question Does hypoxic burden correlate with nocturnal blood pressure and the nondipping pattern in pediatric obstructive sleep apnea (OSA)? Findings In this secondary analysis of a nonrandomized clinical trial that included 190 children… read more here.
Keywords: sleep apnea; hypoxic burden; burden; cardiovascular risk ... See more keywords
Estimating Cardiovascular Benefits of Tirzepatide in Sleep Apnea and Obesity: Insight from the SURMOUNT-OSA Trials
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DOI: 10.1007/s13679-024-00592-x
Abstract: This commentary aims to offer a perspective on the effect of tirzepatide on hypoxic burden and provide indirect evidence of cardiovascular risk reduction after tirzepatide for the treatment of obstructive sleep apnea and obesity. It… read more here.
Keywords: obesity; sleep apnea; apnea obesity; hypoxic burden ... See more keywords
The sleep apnea-specific hypoxic burden predicts incident heart failure.
Sign Up to like & getrecommendations! Published in 2020 at "Chest"
DOI: 10.1016/j.chest.2020.03.053
Abstract: BACKGROUND Heart failure (HF) is a leading cause of morbidity and mortality and while linked to sleep apnea, it is unclear which physiological stressors most strongly associate with incident disease. Here we tested whether Sleep… read more here.
Keywords: heart failure; apnea; hypoxic burden; apnea specific ... See more keywords
Hypoxic burden – definitions, pathophysiological concepts, methods of evaluation, and clinical relevance
Sign Up to like & getrecommendations! Published in 2024 at "Current Opinion in Pulmonary Medicine"
DOI: 10.1097/mcp.0000000000001122
Abstract: Purpose of review Obstructive sleep apnea (OSA) is a common chronic condition that affects over a billion people worldwide and is associated with adverse cardio- and cerebrovascular consequences. Currently, the go-to clinical measure that determines… read more here.
Keywords: review; hypoxic burden; burden; clinical relevance ... See more keywords
Sleep Apnea Specific Hypoxic Burden in Children With Down Syndrome and Typically Developing Children
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Sleep Research"
DOI: 10.1111/jsr.70032
Abstract: Hypoxic burden (HB) is a measure incorporating frequency, depth and duration of respiratory event‐related desaturations. While HB is associated with cardiovascular disease in adults with obstructive sleep apnea (OSA), it has not been assessed in… read more here.
Keywords: hypoxic burden; children syndrome; sleep apnea; mild osa ... See more keywords
Heart Rate Response in OSA: A Clue to Reveal Cardiovascular Benefit from CPAP?
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202205-0984le
Abstract: Obstructive sleep apnea (OSA) is associated with a cluster of serious adverse outcomes, including cardiovascular (CV) morbidity and mortality. However, the protective effect of the first-line therapy of OSA—continuous positive airway pressure (CPAP) against adverse… read more here.
Keywords: benefit cpap; hypoxic burden; rate; heart rate ... See more keywords
Dying with OSA, or from It: A Cautionary Note about Novel Hypoxia Metrics
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202206-1052le
Abstract: Several studies report independent associations between obstructive sleep apnea (OSA) and cardiovascular disease (CVD). However, doubt has recently been cast on the ability of continuous positive airway pressure (CPAP) to mitigate these risks, and the… read more here.
Keywords: spo2; hypoxic burden; hypoxia; desaturation ... See more keywords