A Concerted Redox‐ and Light‐Activated Agent for Controlled Multimodal Therapy against Hypoxic Cancer Cells
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DOI: 10.1002/adma.202210363
Abstract: Hypoxia represents a remarkably exploitable target for cancer therapy, is encountered only in solid human tumors, and is highly associated with cancer resistance and recurrence. Here, a hypoxia‐activated mitochondria‐accumulated Ru(II) polypyridyl prodrug functionalized with conjugated… read more here.
Keywords: cancer; controlled multimodal; agent; hypoxic ... See more keywords
Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy
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DOI: 10.18632/oncotarget.18445
Abstract: Here, we report new mechanistic insight into how chronic hypoxia increases ‘stemness’ in cancer cells. Using chemical inhibitors, we provide direct experimental evidence that ROS production and mitochondrial biogenesis are both required for the hypoxia-induced… read more here.
Keywords: angiogenic therapy; hypoxic cancer; hypoxia; anti angiogenic ... See more keywords