Cardioprotection by AN-7 a prodrug of the histone deacetylase inhibitor butyric acid: Selective activity in hypoxic cardiomyocytes and cardiofibroblasts.
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DOI: 10.1016/j.ejphar.2020.173255
Abstract: The anticancer prodrug butyroyloxymethyl diethylphosphate (AN-7), upon metabolic hydrolysis, releases the histone deacetylase inhibitor butyric acid and imparts histone hyperacetylation. We have shown previously that AN-7 increases doxorubicin-induced cancer cell death and reduces doxorubicin toxicity… read more here.
Keywords: cardiomyocytes cardiofibroblasts; deacetylase inhibitor; histone deacetylase; hypoxic ... See more keywords
Metabolites of Hypoxic Cardiomyocytes Induce the Migration of Cardiac Fibroblasts
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DOI: 10.1159/000456531
Abstract: Background: The migration of cardiac fibroblasts to the infarct region plays a major role in the repair process after myocardial necrosis or damage. However, few studies investigated whether early hypoxia in cardiomyocytes induces the migration… read more here.
Keywords: metabolites hypoxic; migration cardiac; migration; cardiac fibroblasts ... See more keywords