Cardioprotection by AN-7 a prodrug of the histone deacetylase inhibitor butyric acid: Selective activity in hypoxic cardiomyocytes and cardiofibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173255
Abstract: The anticancer prodrug butyroyloxymethyl diethylphosphate (AN-7), upon metabolic hydrolysis, releases the histone deacetylase inhibitor butyric acid and imparts histone hyperacetylation. We have shown previously that AN-7 increases doxorubicin-induced cancer cell death and reduces doxorubicin toxicity… read more here.
Keywords: cardiomyocytes cardiofibroblasts; deacetylase inhibitor; histone deacetylase; hypoxic ... See more keywords
Metabolites of Hypoxic Cardiomyocytes Induce the Migration of Cardiac Fibroblasts
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DOI: 10.1159/000456531
Abstract: Background: The migration of cardiac fibroblasts to the infarct region plays a major role in the repair process after myocardial necrosis or damage. However, few studies investigated whether early hypoxia in cardiomyocytes induces the migration… read more here.
Keywords: metabolites hypoxic; migration cardiac; migration; cardiac fibroblasts ... See more keywords
Salidroside rescues hypoxic cardiomyocytes by regulating the EGLN1/HIF‑1α pathway
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DOI: 10.3892/br.2024.1868
Abstract: Myocardial infarction is characterized by oxygen deficiency caused by arterial flow restriction. Salidroside (SAL) protects against myocardial damage via antioxidant production and inhibition of apoptosis. The present study aimed to investigate potential rescue mechanism of… read more here.
Keywords: sal; hypoxic cardiomyocytes; hypoxia; egln1 hif ... See more keywords