Profiling of nuclear copper-binding proteins under hypoxic condition
Sign Up to like & getrecommendations! Published in 2019 at "BioMetals"
DOI: 10.1007/s10534-019-00171-x
Abstract: Under hypoxic condition, copper (Cu) accumulates in cell nuclei, and regulates the activity of hypoxia-inducible factor-1 (HIF-1) through Cu-binding proteins (CuBPs). To understand the CuBPs in the nucleus, proteomic approach was undertaken to explore the… read more here.
Keywords: hypoxic condition; profiling nuclear; copper; binding proteins ... See more keywords
Selenium Nanoparticles Show Anticancer Activity Through Regulation of HIF-1α and HIF-2α Under Hypoxic Condition in Liver Cancer Cells.
Sign Up to like & getrecommendations! Published in 2023 at "DNA and cell biology"
DOI: 10.1089/dna.2023.0099
Abstract: Tumor microenvironment has significant influence in therapeutic response and clinical outcome. Combination therapy is more effective in cancer treatment compared with monotherapy. Any chemical or drug that targets tumor microenvironment pathway, will be a boon… read more here.
Keywords: cell; condition; hif; hypoxic condition ... See more keywords
The Pivotal Role of Nicotinamide Phosphoribosyl Transferase in Chronic Myeloid Leukemia Cells Under Hypoxic Condition
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-140202
Abstract: Introduction: ABL tyrosine kinase inhibitors (TKIs) improved outcomes for patients with chronic myeloid leukemia (CML) and Philadelphia chromosome (Ph)-positive leukemia. However, ABL TKIs do not eliminate the leukemia stem cells (LSCs) in the bone marrow,… read more here.
Keywords: abl tki; hypoxic condition; treatment; chs828 ... See more keywords
Hypoxia Effects on Trypanosoma cruzi Epimastigotes Proliferation, Differentiation, and Energy Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11080897
Abstract: Trypanosoma cruzi, the causative agent of Chagas disease, faces changes in redox status and nutritional availability during its life cycle. However, the influence of oxygen fluctuation upon the biology of T. cruzi is unclear. The… read more here.
Keywords: metabolism; proliferation; trypanosoma cruzi; hypoxic condition ... See more keywords