Under hypoxic conditions, MSCs affect the expression and methylation level of survival-related genes in ALL independent of apoptosis pathways in-vitro.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2154
Abstract: Mesenchymal stem cells (MSCs) are one of the most prominent cells in the bone marrow. MSCs can affect acute lymphocytic leukemia (ALL) cells under hypoxic conditions. For this aim, we used MOLT-4 cells as simulators… read more here.
Keywords: methylation; affect expression; hypoxic conditions; mscs affect ... See more keywords
Motor-cognitive dual-tasking under hypoxia
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Brain Research"
DOI: 10.1007/s00221-017-5036-y
Abstract: Hypoxic conditions diminish motor performance and cognitive functions, especially when the motor task and the cognitive task are conducted simultaneously. Hypoxia does further increase prefrontal cortex activity which provokes a reduced capability of efficient resource… read more here.
Keywords: dual task; task; hypoxic conditions; motor ... See more keywords
A novel combination treatment to stimulate bone healing and regeneration under hypoxic conditions: photobiomodulation and melatonin
Sign Up to like & getrecommendations! Published in 2017 at "Lasers in Medical Science"
DOI: 10.1007/s10103-017-2145-6
Abstract: Melatonin has anabolic effects on the bone, even under hypoxia, and laser irradiation has been shown to improve osteoblastic differentiation. The aim of this study was to investigate whether laser irradiation and melatonin would have… read more here.
Keywords: hypoxic conditions; treatment; differentiation; melatonin ... See more keywords
Discordant mRNA and protein expression of CXCR4 under in vitro CoCl2-induced hypoxic conditions.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.102
Abstract: Cobalt chloride (CoCl2) has long been accepted as a suitable in vitro hypoxia-mimetic agent. The gene CXCR4, which encodes a chemokine receptor, plays a key role in hypoxic retinal disease. Here, we investigated the mRNA and… read more here.
Keywords: mrna protein; hypoxic conditions; cocl2 induced; cocl2 ... See more keywords
Combined genome-centric metagenomics and stable isotope probing unveils the microbial pathways of aerobic methane oxidation coupled to denitrification process under hypoxic conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Bioresource technology"
DOI: 10.1016/j.biortech.2020.124043
Abstract: Obligate aerobic methanotrophs have been proven to oxidize methane and participate in denitrification under hypoxic conditions. However, this phenomenon and its metabolic mechanism have not been investigated in detail in aerobic methane oxidation coupled to… read more here.
Keywords: hypoxic conditions; methane oxidation; denitrification;
Physiological effects of hypoxic conditions during the plateau period on the chicken embryo.
Sign Up to like & getrecommendations! Published in 2017 at "Comparative biochemistry and physiology. Part A, Molecular & integrative physiology"
DOI: 10.1016/j.cbpa.2016.08.015
Abstract: The chick embryo employs several adaptive responses to hypoxic challenges, affecting both metabolism and oxygen (O2) transport. The present study assessed the effects of hypoxic conditions (17% O2) during the plateau phase on embryonic metabolic… read more here.
Keywords: effects hypoxic; hypoxic conditions; plateau period; conditions plateau ... See more keywords
Proxy evidence from the Gartnerkofel-1 core (Carnic Alps, Austria) for hypoxic conditions in the western Tethys during the end-Permian mass-extinction event
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Geology"
DOI: 10.1016/j.chemgeo.2019.119434
Abstract: Abstract The most severe mass extinction in the Phanerozoic in the latest Permian Period (251.9 Ma), has been attributed to environmental effects related to the massive coeval Siberian flood-basalt eruptions. A potential causal link between the… read more here.
Keywords: hypoxic conditions; western tethys; mass extinction; core ... See more keywords
Photophysical properties and photocytotoxicity of free and liposome-entrapped diazepinoporphyrazines on LNCaP cells under normoxic and hypoxic conditions.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.064
Abstract: 5,7-Diaryl-substituted symmetrical diazepinoporphyrazine and tribenzodiazepinoporphyrazine were synthesized and characterized using UV-Vis, MS MALDI, and various NMR techniques. The expected photosensitizing potentials of these porphyrazines were evaluated by measuring their abilities to generate singlet oxygen in… read more here.
Keywords: properties photocytotoxicity; photocytotoxicity free; lncap cells; hypoxic conditions ... See more keywords
Suppression of the doxorubicin response by hypoxia-inducible factor-1α is strictly dependent on oxygen concentrations under hypoxic conditions.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174845
Abstract: Hypoxia-inducible factor-1α (HIF-1α) and p53 are involved in anticancer drug resistance under hypoxic conditions. Here, we found that the cytotoxicity of anticancer drugs (doxorubicin, gemcitabine, and cisplatin) was lower at 1% O2 than at 5%… read more here.
Keywords: expression; hif; oxygen concentrations; hypoxia inducible ... See more keywords
Decarboxylation of indomethacin induced by heat treatment
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.022
Abstract: ABSTRACT As crystalline indomethacin is heated and subsequently cooled, it transforms into glassy indomethacin. While the original crystals are off‐white in color, the glass becomes blackish‐brown via a yellow intermediate stage. TLC of the components… read more here.
Keywords: hypoxic conditions; indomethacin induced; indomethacin; blackish brown ... See more keywords
Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.6b00417
Abstract: Tirapazamine (TPZ) is an anticancer drug with highly selective cytotoxicity toward hypoxic cells. TPZ is converted to a radical intermediate under hypoxic conditions, and this intermediate interacts with intracellular macromolecules, including DNA. TPZ has been… read more here.
Keywords: hypoxic conditions; dna damage; cytotoxicity; dna ... See more keywords