GDF15 attenuates myocardial hypoxic injury by inhibiting mitochondrial damage through BNIP3 pathway
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DOI: 10.1007/s11033-025-10824-5
Abstract: Growth differentiation factor 15 (GDF15), a hypoxia-responsive mediator in myocardial injury, is established as a mitochondrial stress biomarker in skeletal muscle. However, its mechanistic role in regulating mitophagy during cardiac hypoxia remains unknown. In this… read more here.
Keywords: hypoxic injury; gdf15; hypoxia; injury ... See more keywords
Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model
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DOI: 10.1007/s12264-025-01396-2
Abstract: Hypoxic injury (HI) in the prenatal period often causes neonatal neurological disabilities. Due to the difficulty in obtaining clinical samples, the molecular and cellular mechanisms remain unclear. Here we use vascularized cerebral organoids to investigate… read more here.
Keywords: hypoxic injury; responses hypoxic; injury; vascularized cerebral ... See more keywords
Xentry-Gap19 inhibits Connexin43 hemichannel opening especially during hypoxic injury
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DOI: 10.1007/s13346-020-00763-y
Abstract: Hypoxic injury results in cell death, tissue damage and activation of inflammatory pathways. This is mediated by pathological Connexin43 (Cx43) hemichannel (HC) opening resulting in osmotic and ionic imbalances as well as cytokine production perpetuating… read more here.
Keywords: hemichannel opening; xentry gap19; hypoxic injury; gap19 ... See more keywords
Dalspinin isolated from Spermacoce hispida (Linn.) protects H9c2 cardiomyocytes from hypoxic injury by modulating oxidative stress and apoptosis.
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DOI: 10.1016/j.jep.2019.111962
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Spermacoce hispida (S.hispida), a potential medicinal plant has been traditionally used as an antibacterial, antieczemic, antihypertensive, antidiabetic and antihyperlipidemic agent. Although, this plant has been claimed to protect against oxidative injury and inflammatory… read more here.
Keywords: injury; spermacoce hispida; hypoxic injury; oxidative stress ... See more keywords
Growth Hormone (GH) Crosses the Blood–Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury
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DOI: 10.3390/ijms231911546
Abstract: Several motor, sensory, cognitive, and behavioral dysfunctions are associated with neural lesions occurring after a hypoxic injury (HI) in preterm infants. Growth hormone (GH) expression is upregulated in several brain areas when exposed to HI… read more here.
Keywords: blood brain; barrier bbb; brain barrier; brain ... See more keywords