Association of Hospital Resource Utilization With Neurodevelopmental Outcomes in Neonates With Hypoxic-Ischemic Encephalopathy
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.3770
Abstract: Key Points Question Is higher resource utilization, quantified by hospital costs, associated with survival without neurodevelopmental impairment among infants with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia? Findings In this cohort study of 381 neonates with… read more here.
Keywords: neurodevelopmental outcomes; hypoxic ischemic; neonates hypoxic; resource utilization ... See more keywords
Whole-Blood Gene Expression Profile After Hypoxic-Ischemic Encephalopathy
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.54433
Abstract: This case-control study compares the genome expression at birth and associated outcome in neonates with hypoxic-ischemic encephalopathy in a high-income country (Italy) and their counterparts in low- to middle-income countries (India, Sri Lanka, and Bangladesh). read more here.
Keywords: whole blood; gene expression; hypoxic ischemic; blood gene ... See more keywords
Maternal Social Determinants of Health and Risk of Perinatal Hypoxic-Ischemic Encephalopathy.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2025.1659
Abstract: Importance Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and long-term morbidity. The association between maternal social determinants of health (SDOH) and perinatal HIE has not been established. Objective To examine the association… read more here.
Keywords: perinatal hypoxic; hypoxic ischemic; risk; perinatal hie ... See more keywords
The Activation of PKM2 Induces Pyroptosis in Hippocampal Neurons via the NLRP3/Caspase‐1/GSDMD Pathway in Neonatal Rats With Hypoxic‐Ischemic Brain Injury
Sign Up to like & getrecommendations! Published in 2024 at "Brain and Behavior"
DOI: 10.1002/brb3.70108
Abstract: The presence of hypoxic‐ischemic brain damage (HIBD) in neonates triggers a strong neuroinflammatory reaction. Pyroptosis, a programmed cell death mechanism associated with inflammation, plays a crucial role in HIBD. Pyruvate kinase M2 (PKM2) plays a… read more here.
Keywords: brain; ischemic brain; pkm2; pyroptosis ... See more keywords
Melanin nanoparticles enhance the neuroprotection of mesenchymal stem cells against hypoxic-ischemic injury by inhibiting apoptosis and upregulating antioxidant defense.
Sign Up to like & getrecommendations! Published in 2022 at "Cell biology international"
DOI: 10.1002/cbin.11781
Abstract: Polydopamine nanoparticles are artificial melanin nanoparticles (MNPs) that show strong antioxidant activity. The effects of MNPs on the neuroprotection of mesenchymal stem cells (MSCs) against hypoxic-ischemic injury and the underlying mechanism have not yet been… read more here.
Keywords: mscs; neuroprotection; apoptosis; hypoxic ischemic ... See more keywords
Analysis of long noncoding RNA expression profiles in the whole blood of neonates with hypoxic‐ischemic encephalopathy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28138
Abstract: Long noncoding RNAs (lncRNAs) have been shown to participate in many biological processes. To investigate the expression profiles of lncRNAs and their potential functions in neonatal hypoxic‐ischemic encephalopathy (HIE), we detected the lncRNA and messenger… read more here.
Keywords: long noncoding; expression profiles; hypoxic ischemic; ischemic encephalopathy ... See more keywords
Edaravone Mitigates Hippocampal Neuronal Death and Cognitive Dysfunction by Upregulating BDNF Expression in Neonatal Hypoxic–Ischemic Rats
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10413
Abstract: Neonatal hypoxic–ischemic encephalopathy (HIE) is a severe neurological injury during infancy, often resulting in long‐term cognitive deficits. This study aimed to investigate the neuroprotective effects of Edaravone (EDA), a free radical scavenger, and elucidate the… read more here.
Keywords: hypoxic ischemic; hippocampal neuronal; bdnf expression; hie ... See more keywords
White matter injury in the neonatal hypoxic‐ischemic brain and potential therapies targeting microglia
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24761
Abstract: Neonatal hypoxic–ischemic (H‐I) injury, which mainly causes neuronal damage and white matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy, cognitive and persistent motor disabilities) and mortality. Disruptions to the oxygen… read more here.
Keywords: matter injury; hypoxic ischemic; brain; neonatal hypoxic ... See more keywords
Novel Contrast‐Enhanced Ultrasound Evaluation in Neonatal Hypoxic Ischemic Injury: Clinical Application and Future Directions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.14289
Abstract: Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, and improved survival of neonates with hypoxic ischemic injury. Contrast‐enhanced ultrasound (US) imaging is a novel imaging technique in… read more here.
Keywords: contrast enhanced; ischemic injury; hypoxic ischemic; enhanced ultrasound ... See more keywords
Diffusion pseudonormalization and clinical outcome in term neonates with hypoxic–ischemic encephalopathy
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Radiology"
DOI: 10.1007/s00247-018-4094-z
Abstract: BackgroundPseudonormalization of diffusion-weighted magnetic resonance imaging (MRI) can lead to underestimation of brain injury in newborns with hypoxic–ischemic encephalopathy (HIE), posing a significant problem. We have noticed that some neonates show pseudonormalization negativity on diffusion-weighted… read more here.
Keywords: diffusion; hypoxic ischemic; weighted imaging; diffusion weighted ... See more keywords
Intrapartum fetal monitoring and perinatal risk factors of neonatal hypoxic–ischemic encephalopathy
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-020-05757-2
Abstract: Neonatal hypoxic–ischemic encephalopathy (HIE) in term infants, is a major cause of neonatal mortality and severe neurologic disability. To identify in labor fetal monitoring characteristic patterns and perinatal factors associated with neonatal HIE. Single-center retrospective… read more here.
Keywords: hypoxic ischemic; ischemic encephalopathy; monitoring; hie ... See more keywords