GLOBAL REACH 2018: Iron infusion at high altitude reduces hypoxic pulmonary vasoconstriction equally in both lowlanders and healthy Andean highlanders.
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.08.075
Abstract: BACKGROUND Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in both lowlanders and Sherpa at high altitude. In contrast, the pulmonary vasculature of Andeans suffering with chronic mountain sickness is resistant to iron administration. While pulmonary… read more here.
Keywords: infusion; iron infusion; hypoxic pulmonary; high altitude ... See more keywords
Differences in the microcirculation disturbance in the right and left ventricles of neonatal rats with hypoxic pulmonary hypertension.
Sign Up to like & getrecommendations! Published in 2020 at "Microvascular research"
DOI: 10.1016/j.mvr.2020.104129
Abstract: Microcirculation disturbance is a crucial pathological basis of heart damage; however, microcirculation alterations induced by hypoxic pulmonary hypertension (HPH) remain unknown, and the left ventricle (LV) in HPH is conventionally ignored. Herein, we investigated the… read more here.
Keywords: pulmonary hypertension; hph; microcirculation disturbance; hypoxic pulmonary ... See more keywords
Pannexin 1-a novel regulator of acute hypoxic pulmonary vasoconstriction.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab326
Abstract: AIMS Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia that diverts blood flow from poorly ventilated to better aerated lung areas to optimize ventilation-perfusion matching. Yet, the exact sensory and signaling mechanisms… read more here.
Keywords: pulmonary vasoconstriction; panx1; hypoxic pulmonary; hypoxic ... See more keywords
Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvx076
Abstract: Aims Hypoxic pulmonary vasoconstriction (HPV) redistributes blood flow from poorly ventilated to better aerated areas in the lung, thereby optimizing ventilation-perfusion ratio (V/Q). Pulmonary artery smooth muscle cell (PASMC) contraction in response to hypoxia is… read more here.
Keywords: pulmonary vasoconstriction; response; vasoconstriction; hypoxic pulmonary ... See more keywords
Hypoxic pulmonary vasoconstriction: Building a solid base
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Physiology"
DOI: 10.1113/ep087179
Abstract: Hypoxic vasoconstriction is a response that is seen in the pulmonary circulation but not in any other vascular bed in the body. By diverting blood flow away from less well-ventilated regions in the lung, it… read more here.
Keywords: pulmonary vasoconstriction; response; vasoconstriction; hypoxic pulmonary ... See more keywords
The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aau0296
Abstract: Perfusion-ventilation matching in the lungs requires AMPK-α1 and AMPK-α2 activation downstream of LKB1. Hypoxia amps AMPK Most arteries in the body vasodilate in response to hypoxia. In contrast, pulmonary arteries constrict in response to hypoxia… read more here.
Keywords: pulmonary vasoconstriction; ampk; vasoconstriction; hypoxic pulmonary ... See more keywords
Attenuation of human hypoxic pulmonary vasoconstriction by acetazolamide and methazolamide.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00509.2018
Abstract: RATIONALE Acetazolamide, a carbonic anhydrase inhibitor used for preventing altitude illness attenuates hypoxic pulmonary vasoconstriction (HPV) while improving oxygenation. Methazolamide, an analog of acetazolamide, is more lipophilic, has a longer half-life, and activates a major… read more here.
Keywords: pulmonary vasoconstriction; plasma antioxidant; hypoxic pulmonary; hypoxia ... See more keywords
Bioinformatic Exploration of Hub Genes and Potential Therapeutic Drugs for Endothelial Dysfunction in Hypoxic Pulmonary Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/3677532
Abstract: Hypoxic pulmonary hypertension (HPH) is a fatal chronic pulmonary circulatory disease, characterized by hypoxic pulmonary vascular constriction and remodeling. Studies performed to date have confirmed that endothelial dysfunction plays crucial roles in HPH, while the… read more here.
Keywords: hub genes; hub; hsa mir; hypoxic pulmonary ... See more keywords
Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction".
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/circresaha.119.315826
Abstract: In Response: This response letter addresses discussion initiated by Hüttemann et al in their Letter to the Editor, in response to our article “Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute… read more here.
Keywords: response; oxygen sensing; pulmonary vasoconstriction; hypoxic pulmonary ... See more keywords
Targeting Endothelial ENO1 (Alpha-Enolase) -PI3K-Akt-mTOR Axis Alleviates Hypoxic Pulmonary Hypertension.
Sign Up to like & getrecommendations! Published in 2023 at "Hypertension"
DOI: 10.1161/hypertensionaha.122.19857
Abstract: BACKGROUND It has been shown that glycolytic protein ENO1 (alpha-enolase) contributes to the pathogenesis of pulmonary hypertension through acting smooth muscle cells; however, the roles of ENO1-caused endothelial and mitochondrial dysfunctions in Group 3 pulmonary… read more here.
Keywords: pi3k akt; pulmonary hypertension; hypertension; hypoxic pulmonary ... See more keywords
Hypoxic Pulmonary Vasoconstriction Does Not Explain All Regional Perfusion Redistribution in Asthma
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.201612-2438oc
Abstract: Rationale: Regional hypoventilation in bronchoconstricted patients with asthma is spatially associated with reduced perfusion, which is proposed to result from hypoxic pulmonary vasoconstriction (HPV). Objectives: To determine the role of HPV in the regional perfusion… read more here.
Keywords: perfusion; perfusion redistribution; bronchoconstriction; hypoxic pulmonary ... See more keywords