Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c7ra13295f
Abstract: The promising benefits of salidroside (SAL) in alleviating high altitude sickness boost investigations on its pharmacokinetics and biological activity. However, the transportation and disposition process of SAL under hypoxic conditions has never been explored. The… read more here.
Keywords: sal; hypoxic rats; systemic exposure; cytosolic glucosidase ... See more keywords
Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18061125
Abstract: Chronic hypoxia induces pulmonary hypertension and vascular remodeling, which are clinically relevant to patients with chronic obstructive pulmonary disease (COPD) associated with a decreased level of nitric oxide (NO). Oxidative stress and inflammation play important… read more here.
Keywords: pulmonary hypertension; hypoxic rats; melatonin attenuates; hypertension ... See more keywords
Hypoxia-Induced Kidney Injury in Newborn Rats
Sign Up to like & getrecommendations! Published in 2023 at "Toxics"
DOI: 10.3390/toxics11030260
Abstract: Exposure to hypoxia during the early postnatal period can have adverse effects on vital organs. Neonatal Sprague–Dawley rats housed in a hypoxic chamber were compared to those in a normoxic chamber from postnatal days 0… read more here.
Keywords: hypoxia induced; kidneys hypoxic; kidney; kidney injury ... See more keywords
Hypoxia in utero increases the risk of pulmonary hypertension in rat offspring and is associated with vasopressin type-2 receptor upregulation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11533
Abstract: Pulmonary hypertension (PH) in newborns and adults is a disease that can lead to right heart failure and result in a shorter lifespan. PH was induced by maintaining pregnant rats in a hypoxic chamber for… read more here.
Keywords: hypoxia utero; pulmonary hypertension; control; hypoxic rats ... See more keywords