Effects of hypoxia and nanocarrier size on pH-responsive nano-delivery system to solid tumors
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DOI: 10.1038/s41598-021-98638-w
Abstract: One of the special features of solid tumors is the acidity of the tumor microenvironment, which is mainly due to the presence of hypoxic regions. Therefore, pH-responsive drug delivery systems have recently been highly welcomed.… read more here.
Keywords: solid tumors; delivery system; delivery; drug ... See more keywords
Elimination of Induced Hypoxic Regions in Depth of 3D Porous Silk Scaffolds by the Introduction of Channel Configuration
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DOI: 10.1155/2022/9767687
Abstract: Development of large, clinically sized tissue constructs with efficient mass transport is a tremendous need in tissue engineering. One major challenge in large tissue-engineered constructs is to support homogeneous delivery of oxygen and nutrients throughout… read more here.
Keywords: regions depth; hypoxic regions; porous silk; induced hypoxic ... See more keywords
HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells
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DOI: 10.1186/s12885-018-4577-1
Abstract: BackgroundHypoxia stimulates metastasis in cancer and is linked to poor patient prognosis. In tumours, oxygen levels vary and hypoxic regions exist within a generally well-oxygenated tumour. However, whilst the heterogeneous environment is known to contribute… read more here.
Keywords: hif1 alpha; hypoxic regions; response; cancer ... See more keywords
Bacteria-Driven Tumor Microenvironment-Sensitive Nanoparticles Targeting Hypoxic Regions Enhances the Chemotherapy Outcome of Lung Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s396863
Abstract: Background Chemotherapy still plays a dominant role in cancer treatment. However, the inability of conventional chemotherapeutic drugs to reach the hypoxic zone of solid tumors significantly weakens their efficacy. Bacteria-mediated drug delivery systems can be… read more here.
Keywords: hypoxic regions; ptx nps; bif; cancer ... See more keywords