Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1α to modulate hypoxic responses in chondrocytes.
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DOI: 10.1016/j.cellsig.2017.05.001
Abstract: Hypoxia-inducible factor 1-alpha (HIF-1α) is a DNA-binding transcription factor regulating hypoxic responses. It plays a key role in vascularization and angiogenesis as well as various metabolic pathways. Interestingly, during early phase endochondral ossification when HIF… read more here.
Keywords: degradation; hif; hypoxic responses; oxygen concentration ... See more keywords