Thylakoid Membranes with Unique Photosystems Used to Simultaneously Produce Self-Supplying Oxygen and Singlet Oxygen for Hypoxic Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202001666
Abstract: Photodynamic therapy (PDT) efficacy has been dramatically limited by the insufficient oxygen (O2 ) level in hypoxic tumors. Although various PDT nanosystems have been designed to deliver or produce O2 in support of reactive oxygen… read more here.
Keywords: oxygen; thylakoid membranes; singlet oxygen; therapy ... See more keywords
An NIR‐II Photothermally Triggered “Oxygen Bomb” for Hypoxic Tumor Programmed Cascade Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202201978
Abstract: Hypoxia, as a characteristic feature of solid tumors, has a close relationship with tumor resistance to photodynamic therapy (PDT) and chemotherapy. Perfluorocarbon (PFC) is reported to relieve hypoxic in solid tumors by acting as an… read more here.
Keywords: hypoxic tumor; oxygen bomb; programmed cascade; cascade therapy ... See more keywords
Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202202625
Abstract: In cancer radiotherapy, the lack of fixed DNA damage by oxygen in hypoxic microenvironment of solid tumors often leads to severe radioresistance. Nitric oxide (NO) is a potent radiosensitizer that acts in two ways. It… read more here.
Keywords: hypoxic tumor; normalization radiosensitization; tumor vessel; nitric oxide ... See more keywords
Volume effects in the TCP for hypoxic and oxygenated tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Medical physics"
DOI: 10.1002/mp.14257
Abstract: PURPOSE Clinical studies in radiation therapy with conventional fractionation show a reduction in the tumor control probability (TCP) with an increase in the total and hypoxic tumor volumes. The main objective of this article is… read more here.
Keywords: tumor; total tumor; volume; tumor volumes ... See more keywords
Dual-Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O2 Self-Sufficient Nanoplatform.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201701621
Abstract: Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO2 ) with O2 self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through a… read more here.
Keywords: dual stage; tumor; stage light; self sufficient ... See more keywords
Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00433
Abstract: Both nitroreductase and the folate receptor are highly expressed in hypoxic tumors. The folate receptor is a potential target for tumors, and nitroreductase can selectively turn on the fluorescence of probes by reducing the nitro… read more here.
Keywords: strategy; fluorescent probe; fluorescent; hypoxic tumor ... See more keywords
Ultrasound-Induced Piezocatalysis Triggered NO Generation for Enhanced Hypoxic Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c00603
Abstract: Conventional NO gas generation based on l-arginine (l-Arg) is usually dependent on H2O2 and O2, both of which are very limited within the tumor microenvironment, thus greatly limiting l-Arg's therapeutic effect. Herein, a novel nanoplatform… read more here.
Keywords: hypoxic tumor; ultrasound induced; induced piezocatalysis; generation ... See more keywords
pH-Sensitive Multiligand Gold Nanoplatform Targeting Carbonic Anhydrase IX Enhances the Delivery of Doxorubicin to Hypoxic Tumor Spheroids and Overcomes the Hypoxia-Induced Chemoresistance.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b05607
Abstract: Hypoxia is a common feature of solid tumors contributing to resistance to chemotherapy. Selective delivery of chemotherapeutic drugs to hypoxic tumor niche remains an unsolved issue. For this purpose, we constructed a gold nanoplatform targeting… read more here.
Keywords: tumor; nanoplatform; gold nanoplatform; delivery ... See more keywords
Selective turn-on near-infrared fluorescence probe for hypoxic tumor cell imaging
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DOI: 10.1039/c7ra01466j
Abstract: Hypoxia is a typical feature of solid tumors. To detect hypoxic tumor cells, we designed new selective turn-on probes by conjugating (1-methyl-2-nitro-1H-imidazol-5-yl)methanol to the near-infrared fluorescence probe DCPO through an ether linkage and bis-carbamate linkage… read more here.
Keywords: selective turn; probe; near infrared; fluorescence probe ... See more keywords
Hypoxic tumor therapy based on free radicals
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DOI: 10.1039/d3qm00206c
Abstract: Hypoxia is an intrinsic characteristic of many malignant solid tumors, contributing largely to tumor progression and metastasis, as well as resistance to most standard therapeutic modalities, such as radiotherapy, chemotherapy.... read more here.
Keywords: hypoxic tumor; based free; tumor therapy; therapy based ... See more keywords
Advances in nanomaterials for treatment of hypoxic tumor
Sign Up to like & getrecommendations! Published in 2021 at "National Science Review"
DOI: 10.1093/nsr/nwaa160
Abstract: Abstract The hypoxic tumor microenvironment is characterized by disordered vasculature and rapid proliferation of tumors, resulting from tumor invasion, progression and metastasis. The hypoxic conditions restrict efficiency of tumor therapies, such as chemotherapy, radiotherapy, phototherapy… read more here.
Keywords: oxygen; tumor; generating nanomaterials; advances nanomaterials ... See more keywords