Targeting DNA topoisomerase IIα (TOP2A) in the hypoxic tumour microenvironment using unidirectional hypoxia‐activated prodrugs (uHAPs)
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DOI: 10.1002/iub.2619
Abstract: The hypoxic tumour microenvironment (hTME), arising from inadequate and chaotic vascularity, can present a major obstacle for the treatment of solid tumours. Hypoxic tumour cells compromise responses to treatment since they can generate resistance to… read more here.
Keywords: tumour microenvironment; unidirectional hypoxia; top2a; activated prodrugs ... See more keywords