Development of a reliable, sensitive, and convenient assay for the discovery of new eIF5A hypusination inhibitors
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DOI: 10.1371/journal.pone.0308049
Abstract: eIF5A is a translation factor dysregulated in several pathologies such as cancer and diabetes. eIF5A activity depends upon its hypusination, a unique post-translational modification catalyzed by two enzymes: DHPS and DOHH. Only a few molecules… read more here.
Keywords: eif5a hypusination; hyp assay; hypusination inhibitors; convenient ... See more keywords