CLICs Inhibitor IAA94 Alleviates Inflammation and Injury in Septic Liver by Preventing Pyroptosis in Macrophages.
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DOI: 10.1007/s10753-025-02304-6
Abstract: Macrophage pyroptosis represents a pivotal mechanism underlying acute liver injury during sepsis. Chloride intracellular channel proteins (CLICs) have been linked to inflammatory reflexes, with IAA94 serving as an inhibitor of channel formation characteristic of CLICs.… read more here.
Keywords: pyroptosis; alleviates inflammation; iaa94 alleviates; injury ... See more keywords