Targeting tumor metabolic flexibility enhances radiotherapeutic efficacy via mitochondrial complex I Inhibition in an intracranial S180 sarcoma mouse model.
Sign Up to like & getrecommendations! Published in 2025 at "Scientific reports"
DOI: 10.1038/s41598-025-29326-2
Abstract: Radiotherapy (RT) eliminates cancer cells by inducing DNA damage. However, its efficacy is often reduced by mechanisms such as radiation resistance, effective DNA repair, and hypoxia within tumors. Tumor cells utilize metabolic flexibility, dynamically switching… read more here.
Keywords: iacs; sarcoma; mitochondrial complex; tumor ... See more keywords
RBIO-05. Mitochondrial complex I inhibitor, IACS synergistically enhances the radio-therapeutic effect for the intracranial S180 sarcoma mouse model
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1545
Abstract: Radiotherapy (RT) eliminates cancer cells by inducing DNA damage. However, its efficacy is often reduced by mechanisms such as radiation resistance, effective DNA repair, and hypoxia within tumors. Tumor cells utilize metabolic flexibility, dynamically switching… read more here.
Keywords: s180 sarcoma; iacs; mitochondrial complex; tumor ... See more keywords