Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04291d
Abstract: Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion… read more here.
Keywords: aggregation; endogenous inhibition; inhibition iapp; iapp ... See more keywords
Metabolism-insulin secretion coupling in pancreatic beta-cells: the protective role of urolithin B towards IAPP aggregation, insulin release and mitochondrial respiration
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5790088
Abstract: Intracellular aggregation and pancreatic deposition of Islet Amyloid Polypeptide (IAPP, or amylin) is an important trigger of β-cell dysfunction in type 2 diabetes and prevention of this process represents an attractive strategy to improve β-cell… read more here.
Keywords: aggregation; cell; iapp aggregation; physiology ... See more keywords
Nonhuman IAPP Variants Inhibit Human IAPP Aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "Protein and peptide letters"
DOI: 10.2174/0929866528666210806152706
Abstract: AIM To identify naturally occurring variants of IAPP capable of inhibiting the aggregation of human IAPP and protecting living cells from the toxic effects of human IAPP. BACKGROUND The loss of insulin-producing β-cells and the… read more here.
Keywords: aggregation; iapp variants; capable inhibiting; iapp aggregation ... See more keywords