Effects of Protein Corona on IAPP Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity
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DOI: 10.1038/s41598-017-02597-0
Abstract: Aggregation of islet amyloid polypeptide (IAPP), a peptide hormone co-synthesized and co-stored with insulin in pancreatic cells and also co-secreted to the circulation, is associated with beta-cell death in type-2 diabetes (T2D). In T2D patients… read more here.
Keywords: aggregation; iapp; effects protein; aggregation fibril ... See more keywords
Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation
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DOI: 10.3390/biom11030411
Abstract: Amyloid-formation by the islet amyloid polypeptide (IAPP), produced by the β-cells in the human pancreas, has been associated with the development of type II diabetes mellitus (T2DM). The human plasma-protein transthyretin (TTR), a well-known amyloid-inhibiting… read more here.
Keywords: ttr; inhibition iapp; formation; iapp amyloid ... See more keywords