iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance
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DOI: 10.1073/pnas.2111380119
Abstract: Significance Accumulating preclinical and clinical evidence has supported a central role for alterations in Ca2+ homeostasis in the development of cancer. TMCO1 protein is an identified Ca2+-channel protein, while its roles in cancer remain obscure.… read more here.
Keywords: iaspp tmco1; cancer; ca2 homeostasis; degradation ... See more keywords