Chronic serotonin reuptake inhibition uncouples brown fat mitochondria and induces beiging/browning process of white fat in overfed rats.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117307
Abstract: AIM To investigate whether a chronic 5-HT reuptake inhibitor (i.e. Fluoxetine-FLX) exposure in young adult rats overfed during suckling period would modulate interscapular brown adipose tissue (iBAT) mitochondria and browning agents in white adipose tissue… read more here.
Keywords: ibat; group; adipose tissue; group overfed ... See more keywords
Odevixibat: an investigational inhibitor of the ileal bile acid transporter (IBAT) for the treatment of biliary atresia
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2151890
Abstract: ABSTRACT Introduction Biliary atresia (BA) is a rare, non-curable cholestasis-causing disease in infancy, due to progressive ascending bile duct sclerosis. Even after restoration of bile flow following Kasai portoenterostomy, about half of these children need… read more here.
Keywords: biliary atresia; bile acid; bile acids; acid transporter ... See more keywords
Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions
Sign Up to like & getrecommendations! Published in 2022 at "Adipocyte"
DOI: 10.1080/21623945.2022.2111053
Abstract: ABSTRACT Interscapular brown adipose tissue (iBAT) of both rabbits and humans exhibits a similar whitening phenomenon under physiological conditions. However, a detailed characterization of iBAT whitening in them is still lacking. Here, we chose rabbits… read more here.
Keywords: interscapular brown; brown adipose; adipose tissue; analysis ... See more keywords
The sympathetic innervation suppresses the autophagic-lysosomal system in brown adipose tissue under basal and cold-stimulated conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00065.2019
Abstract: The Sympathetic Nervous System (SNS) activates cAMP signaling and promotes trophic effects on brown adipose tissue through poorly understood mechanisms. Because norepinephrine has been found to induce anti-proteolytic effects on muscle and heart, we hypothesized… read more here.
Keywords: system; ibat; adipose tissue; brown adipose ... See more keywords
Anatomical Determinants of Leptin and Melanocortins Regulation of Cardiovascular and Metabolic Autonomic Neurocircuitries
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730319
Abstract: The central nervous system (CNS) autonomic network plays an important role in regulation of cardiovascular and metabolic functions. Leptin, a hormone secreted by adipose tissue, acts in the brain to regulate energy homeostasis, cardiovascular function,… read more here.
Keywords: localization; lepr neurons; cardiovascular metabolic; kidney ... See more keywords
Exploring the relationship of brown adipose tissue to bone microarchitecture using 7T MRI and micro-CT.
Sign Up to like & getrecommendations! Published in 2022 at "Histology and histopathology"
DOI: 10.14670/hh-18-481
Abstract: BACKGROUND Brown adipose tissue (BAT) is involved both in energy production and bone metabolism. The purpose of this study was to analyze the relationship between BAT and microarchitecture at cancellous and cortical bone using Kunming… read more here.
Keywords: microarchitecture; bone; adipose tissue; bat ... See more keywords
Cerenkov luminescence imaging of interscapular brown adipose tissue using a TSPO-targeting PET probe in the UCP1 ThermoMouse
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DOI: 10.7150/thno.74828
Abstract: Rationale: [18F]fluorodeoxyglucose-positron emission tomography ([18F]FDG-PET) has been widely used as an imaging technique to measure interscapular brown adipose tissue (iBAT) activity. However, it is challenging to obtain iBAT-specific images using [18F]FDG-PET because increased uptake of… read more here.
Keywords: tspo targeting; ucp1 thermomouse; pet; ibat ... See more keywords