An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2163838
Abstract: Conflicting evidence exists on the association between consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic worsening of inflammatory bowel disease (IBD). We hypothesise that the heterogeneous prevalence of pathobionts [e.g., adherent-invasive Escherichia coli (AIEC)], might… read more here.
Keywords: ibd associated; inflammasome caspase; associated pathobiont; colitis ... See more keywords
Pathophysiology of IBD associated diarrhea
Sign Up to like & getrecommendations! Published in 2018 at "Tissue Barriers"
DOI: 10.1080/21688370.2018.1463897
Abstract: ABSTRACT Inflammatory bowel diseases broadly categorized into Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing prevalence worldwide. The etiology of the disease is complex and involves… read more here.
Keywords: associated diarrhea; ibd associated; barrier function; diarrhea ... See more keywords
hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/2828981
Abstract: Background Intestinal fibrosis, one of the complications of inflammatory bowel disease (IBD), is associated with fistula and intestinal stricture formation. There are currently no treatments for fibrosis. Mesenchymal stem cell-derived exosomes have been proven to… read more here.
Keywords: intestinal fibroblasts; ibd associated; erk phosphorylation; intestinal fibrosis ... See more keywords