Underground ibogaine use for the treatment of substance use disorders: A qualitative analysis of subjective experiences.
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DOI: 10.1111/dar.13587
Abstract: INTRODUCTION Ibogaine is one of the alkaloids naturally found in plants such as Tabernanthe iboga, which has been traditionally used by members of the Bwiti culture. Since the discovery of its anti-addictive properties by Howard… read more here.
Keywords: substance use; underground ibogaine; ibogaine; treatment ... See more keywords
Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes
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DOI: 10.3389/fphar.2018.00529
Abstract: Ibogaine may be effective for transitioning opioid and cocaine dependent individuals to sobriety. American and European self-help groups provided public testimonials that ibogaine alleviated drug craving and opioid withdrawal symptoms after only a single dose… read more here.
Keywords: opioid withdrawal; ibogaine; treatment; detoxification ... See more keywords
Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice
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DOI: 10.3389/fphar.2021.739012
Abstract: Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae), natural from Africa, and has been proposed as a potential treatment for substance use disorders. In animal models, ibogaine reduces ethanol self-administration. However,… read more here.
Keywords: ibogaine; reinstatement; treatment; drug ... See more keywords
Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites
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DOI: 10.3389/fphar.2022.855000
Abstract: The psychedelic alkaloid ibogaine is increasingly used as an oral treatment for substance use disorders, despite being unlicensed in most countries and having reported adverse events. Using wild-type and genetically modified mice, we investigated the… read more here.
Keywords: cyp3a4; ibogaine; plasma; ibogaine metabolites ... See more keywords
Ibogaine Induces Cardiotoxic Necrosis in Rats—The Role of Redox Processes
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DOI: 10.3390/ijms25126527
Abstract: Ibogaine is an organic indole alkaloid that is used in alternative medicine to combat addiction. Numerous cases of life-threatening complications and sudden deaths associated with ibogaine use have been reported, and it has been hypothesized… read more here.
Keywords: redox processes; ibogaine; necrosis; role redox ... See more keywords